Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.64 |
| ▸ | THRB | P10828 | 1/20 | 0.64 |
| ▸ | MTOR | P42345 | 1/20 | 0.64 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.64 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.64 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.64 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | GLA | P06280 | 1/20 | 0.53 |
| ▸ | P2RY2 | P41231 | 1/20 | 0.53 |
| ▸ | ST6GAL1 | P15907 | 5/20 | 0.51 |
| ▸ | PNP | P00491 | 1/20 | 0.51 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4585577 | 0.90 | LMNA (0.64) | LMNATHRBMTORMDM2NCOA1 | |
| SCHEMBL441997 | 0.89 | LMNA (0.66) | LMNATHRBMTORMDM2NCOA1 | |
| SCHEMBL13678671 | 0.89 | LMNA (0.66) | LMNATHRBMTORMDM2NCOA1 | |
| Hydrochloric Acid SCHEMBL11858047 | 0.89 | LMNA (0.62) | LMNATHRBMTORMDM2NCOA1 | |
| Hydrochloric Acid SCHEMBL11852550 | 0.88 | LMNA (0.65) | LMNATHRBMTORMDM2NCOA1 | |
| SCHEMBL5985845 | 0.88 | LMNA (0.61) | LMNATHRBMTORMDM2NCOA1 | |
| SCHEMBL331768 | 0.86 | LMNA (0.70) | LMNATHRBMTORMDM2NCOA1 | |
| SCHEMBL30608768 | 0.86 | LMNA (0.74) | LMNATHRBMTORMDM2NCOA1 | |
| SCHEMBL6060610 | 0.85 | LMNA (0.69) | LMNATHRBMTORMDM2NCOA1 | |
| SCHEMBL236108 | 0.85 | LMNA (0.69) | LMNATHRBMTORMDM2NCOA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1915053-A2 | NOVEL 2'-C-METHYL AND 4'-C-METHYL NUCLEOSIDE DERIVATIVES | Merck & Co., Inc. (US) | 2008-04-30 | — | — | EP | disclosed |
| WO-2007022073-A2 | NOVEL 2'-C-METHYL AND 4'-C-METHYL NUCLEOSIDE DERIVATIVES | MERCK & CO., INC. (US) | 2007-02-22 | — | — | WO | disclosed |