SCHEMBL441997

SCHEMBL441997

Nc1ccn([C@@H]2O[C@H](COC(=O)c3ccccc3)[C@@H](O)[C@H]2O)c(=O)n1

nearest known ligand 0.66

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
LMNA P02545 1/20 0.66
THRB P10828 1/20 0.66
MTOR P42345 1/20 0.66
MDM2 Q00987 1/20 0.66
NCOA1 Q15788 1/20 0.66
NCOA3 Q9Y6Q9 1/20 0.66
ST6GAL1 P15907 5/20 0.61
ALDH1A1 P00352 2/20 0.58
L3MBTL1 Q9Y468 1/20 0.55
TSHR P16473 1/20 0.55
GLA P06280 1/20 0.55
NT5E P21589 1/20 0.55
P2RY6 Q15077 1/20 0.55
P2RY14 Q15391 1/20 0.55
P2RY2 P41231 1/20 0.55
HTT P42858 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13678671 1.00 LMNA (0.66) LMNATHRBMTORMDM2NCOA1
Hydrochloric Acid SCHEMBL11852550 0.99 LMNA (0.65) LMNATHRBMTORMDM2NCOA1
SCHEMBL1525218 0.91 ALDH1A1 (0.56) LMNATHRBMTORMDM2NCOA1
SCHEMBL9868833 0.90 LMNA (0.59) LMNATHRBMTORMDM2NCOA1
SCHEMBL30608768 0.90 LMNA (0.74) LMNATHRBMTORMDM2NCOA1
SCHEMBL28197797 0.90 LMNA (0.55) LMNATHRBMTORMDM2NCOA1
SCHEMBL4665032 0.89 LMNA (0.64) LMNATHRBMTORMDM2NCOA1
SCHEMBL4585577 0.89 LMNA (0.64) LMNATHRBMTORMDM2NCOA1
SCHEMBL4586059 0.89 LMNA (0.58) LMNATHRBMTORMDM2NCOA1
SCHEMBL4450358 0.89 ALDH1A1 (0.54) LMNATHRBMTORMDM2NCOA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 244 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2022123501-A1 PROTECTED DEOXYDIDEHYDRO-NUCLEOSIDES VICTORIA LINK LIMITED (NZ) 2022-06-16 WO claimed
CN-1012366-B The preparation of cytidine(C TAKEDA CHEMICAL INDUSTRIES LTD (JP) 1991-04-17 CN claimed
EP-0193903-B1 PRODUCTION OF CYTOSINE NUCLEOSIDES Takeda Chemical Industries, Ltd. (JP) 1990-06-13 EP claimed
EP-0193903-A2 Production of cytosine nucleosides Takeda Chemical Industries, Ltd. (JP) 1986-09-10 EP claimed
US-20260071217-A1 ANTISENSE OLIGOMER COMPOUNDS SAREPTA THERAPEUTICS, INC. (US) 2026-03-12 US disclosed
CN-116970014-B Preparation method and application of N-heterocyclic carbene catalyzed selectively acylated nucleoside derivative 贵州大学 2026-02-27 CN disclosed
US-20250241940-A1 MODIFIED ANTISENSE OLIGOMERS FOR EXON INCLUSION IN SPINAL MUSCULAR ATROPHY JPMORGAN CHASE BANK, N.A. AS ADMINISTRATIVE AGENT 2025-07-31 US disclosed
US-20250171783-A1 ANTISENSE-INDUCED EXON2 INCLUSION IN ACID ALPHA-GLUCOSIDASE SAREPTA THERAPEUTICS, INC. 2025-05-29 US disclosed
US-20250171779-A1 ANTISENSE OLIGOMERS AND METHODS OF USING THE SAME FOR TREATING DISEASES ASSOCIATED WITH THE ACID ALPHA-GLUCOSIDASE GENE SAREPTA THERAPEUTICS, INC. (US) 2025-05-29 US disclosed
US-20240415857-A1 ANTISENSE-INDUCED EXON EXCLUSION IN TYPE VII COLLAGEN JPMORGAN CHASE BANK, N.A. AS ADMINISTRATIVE AGENT 2024-12-19 US disclosed
US-12139709-B2 Antisense oligomers and methods of using the same for treating diseases associated with the acid alpha-glucosidase gene SAREPTA THERAPEUTICS, INC. (US) 2024-11-12 US disclosed
US-12121532-B2 Modified antisense oligomers for exon inclusion in spinal muscular atrophy SAREPTA THERAPEUTICS, INC. (US) 2024-10-22 US disclosed
CN-1012366-B The preparation of cytidine(C TAKEDA CHEMICAL INDUSTRIES LTD (JP) 1991-04-17 CN disclosed
EP-0193903-B1 PRODUCTION OF CYTOSINE NUCLEOSIDES Takeda Chemical Industries, Ltd. (JP) 1990-06-13 EP disclosed
EP-0270651-A4 NOVEL DEOXYRIBONUCLEOSIDE PHOSPHORAMIDITES AND THEIR USE FOR THE PREPARATION OF OLIGONUCLEOTIDES. CALIFORNIA INST OF TECHN (US) 1989-03-29 EP disclosed
EP-0270651-A1 NOVEL DEOXYRIBONUCLEOSIDE PHOSPHORAMIDITES AND THEIR USE FOR THE PREPARATION OF OLIGONUCLEOTIDES. CALIFORNIA INST OF TECHN (US) 1988-06-15 EP disclosed
EP-0260032-A2 Compounds for the cleavage at a specific position of RNA, oligomers employed for the formation of said compounds, and starting materials for the synthesis of said oligomers AJINOMOTO CO., INC. (JP) 1988-03-16 EP disclosed
WO-1988000201-A1 NOVEL DEOXYRIBONUCLEOSIDE PHOSPHORAMIDITES AND THEIR USE FOR THE PREPARATION OF OLIGONUCLEOTIDES CALIFORNIA INSTITUTE OF TECHNOLOGY, INC. (US) 1988-01-14 WO disclosed
CN-86101400-A The preparation of cytidine(C 1986-09-10 CN disclosed
EP-0191869-A1 FISH CALCITONIN DERIVATIVE, PROCESS FOR ITS PREPARATION, AND GENE SYSTEM THEREFOR HODOGAYA CHEMICAL COMPANY, LIMITED (JP) 1986-08-27 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240415857-A1 ANTISENSE-INDUCED EXON EXCLUSION IN TYPE VII COLLAGEN COL2A1, COL14A1, UPF1 LMNA 259/4885THRB 2845/4885MTOR 4864/4885
US-12139709-B2 Antisense oligomers and methods of using the same for treating diseases associated with the acid alpha-glucosidase gene GAA, GBA3, GBA1 LMNA 352/4885THRB 3335/4885MTOR 4712/4885
US-12121532-B2 Modified antisense oligomers for exon inclusion in spinal muscular atrophy SMN1; SMN2, UPF1, RBM17 LMNA 439/4885THRB 3399/4885MTOR 4059/4885
US-20260071217-A1 ANTISENSE OLIGOMER COMPOUNDS DCLRE1B, OGG1, DCTD LMNA 1735/4885THRB 1813/4885MTOR 3503/4885
US-20250171779-A1 ANTISENSE OLIGOMERS AND METHODS OF USING THE SAME FOR TREATING DISEASES ASSOCIATED WITH THE ACID ALPHA-GLUCOSIDASE GENE GAA, GBA3, GBA1 LMNA 352/4885THRB 3335/4885MTOR 4712/4885
US-20250241940-A1 MODIFIED ANTISENSE OLIGOMERS FOR EXON INCLUSION IN SPINAL MUSCULAR ATROPHY SMN1; SMN2, UPF1, RBM17 LMNA 439/4885THRB 3399/4885MTOR 4059/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.