Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.67 |
| ▸ | TP53 | P04637 | 3/20 | 0.48 |
| ▸ | TACR3 | P29371 | 5/20 | 0.44 |
| ▸ | PTGFR | P43088 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | TACR2 | P21452 | 2/20 | 0.41 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4665278 | 0.99 | LMNA (0.66) | LMNATP53TACR3PTGFRMAPT | |
| SCHEMBL4668637 | 0.94 | LMNA (0.59) | LMNATP53TACR3ALDH1A1HPGD | |
| SCHEMBL4665270 | 0.93 | LMNA (0.58) | LMNATP53TACR3ALDH1A1HPGD | |
| SCHEMBL4667106 | 0.91 | LMNA (0.64) | LMNATP53TACR3PTGFRMAPT | |
| SCHEMBL4665275 | 0.90 | LMNA (0.64) | LMNATP53TACR3PTGFRMAPT | |
| SCHEMBL4668568 | 0.86 | LMNA (0.50) | LMNATP53TACR3ALDH1A1HPGD | |
| SCHEMBL4667478 | 0.86 | LMNA (0.56) | LMNATP53TACR3MAPTALDH1A1 | |
| SCHEMBL4667525 | 0.86 | LMNA (0.50) | LMNATP53TACR3 | |
| SCHEMBL4667111 | 0.85 | LMNA (0.49) | LMNATP53TACR3 | |
| SCHEMBL4667076 | 0.85 | LMNA (0.48) | LMNATP53TACR3TACR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1940795-A1 | N-OXO-HETEROCYCLE AND N-OXO-ALKYL QUINOLINE-4-CARBOXAMIDES AS NK-3 RECEPTOR LIGANDS | AstraZeneca AB (SE) | 2008-07-09 | — | — | EP | disclosed |
| WO-2007035156-A1 | N-OXO-HETEROCYCLE AND N-OXO-ALKYL QUINOLINE-4-CARBOXAMIDES AS NK-3 RECEPTOR LIGANDS | ASTRAZENECA AB (SE) | 2007-03-29 | — | — | WO | disclosed |