Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | TACR3 | P29371 | 11/20 | 0.45 |
| ▸ | TACR2 | P21452 | 10/20 | 0.45 |
| ▸ | OPRM1 | P35372 | 6/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | TRPV4 | Q9HBA0 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4665926 | 1.00 | LMNA (0.48) | LMNATACR3TACR2OPRM1TP53 | |
| SCHEMBL4665219 | 0.93 | TACR3 (0.47) | LMNATACR3TACR2OPRM1TP53 | |
| SCHEMBL4667069 | 0.91 | TACR3 (0.47) | LMNATACR3TACR2OPRM1KCNH2 | |
| SCHEMBL4665278 | 0.86 | LMNA (0.66) | LMNATACR3TACR2OPRM1TP53 | |
| SCHEMBL4665273 | 0.85 | LMNA (0.67) | LMNATACR3TACR2TP53 | |
| SCHEMBL6625208 | 0.84 | LMNA (0.53) | LMNATACR3TACR2OPRM1TP53 | |
| SCHEMBL4665270 | 0.84 | LMNA (0.58) | LMNATACR3TACR2OPRM1TP53 | |
| SCHEMBL4668637 | 0.83 | LMNA (0.59) | LMNATACR3TACR2TP53 | |
| SCHEMBL7003424 | 0.82 | LMNA (0.50) | LMNATACR3TACR2OPRM1TP53 | |
| SCHEMBL6626579 | 0.81 | ALDH1A1 (0.56) | LMNATACR3TACR2OPRM1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1940795-A1 | N-OXO-HETEROCYCLE AND N-OXO-ALKYL QUINOLINE-4-CARBOXAMIDES AS NK-3 RECEPTOR LIGANDS | AstraZeneca AB (SE) | 2008-07-09 | — | — | EP | claimed |
| WO-2007035156-A1 | N-OXO-HETEROCYCLE AND N-OXO-ALKYL QUINOLINE-4-CARBOXAMIDES AS NK-3 RECEPTOR LIGANDS | ASTRAZENECA AB (SE) | 2007-03-29 | — | — | WO | claimed |