Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.32 |
| ▸ | HTR2C | P28335 | 1/20 | 0.32 |
| ▸ | HTR6 | P50406 | 1/20 | 0.31 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.31 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.30 |
| ▸ | KHK | P50053 | 1/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20577428 | 0.88 | HTR6 (0.46) | HTR6KHK | |
| SCHEMBL3159987 | 0.82 | HTR6 (0.41) | HPGDKMT2ASMN1; SMN2HTR2AHTR2C | |
| SCHEMBL2554838 | 0.79 | KMT2A (0.44) | HPGDKMT2ASMN1; SMN2HTR2AHTR2C | |
| SCHEMBL1479533 | 0.79 | KMT2A (0.42) | KMT2ASMN1; SMN2KHK | |
| Hydrochloric Acid SCHEMBL15352805 | 0.78 | KMT2A (0.41) | HPGDKMT2ASMN1; SMN2KHK | |
| SCHEMBL3309077 | 0.78 | CHRM5 (0.39) | HPGDKMT2ASMN1; SMN2SIGMAR1HRH3 | |
| SCHEMBL27349923 | 0.78 | CXCR4 (0.38) | HTR6L3MBTL3L3MBTL1 | |
| Hydrochloric Acid SCHEMBL26135888 | 0.77 | KMT2A (0.47) | HPGDKMT2ASMN1; SMN2HTR2AHTR2C | |
| SCHEMBL25955427 | 0.77 | SIGMAR1 (0.32) | KMT2ASIGMAR1 | |
| SCHEMBL310984 | 0.76 | SIGMAR1 (0.38) | SIGMAR1KHK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1889836-B1 | NOVEL PYRIDINE DERIVATIVE AND PYRIMIDINE DERIVATIVE (3) | EISAI R&D MAN CO LTD (JP) | 2013-06-12 | — | — | EP | disclosed |
| EP-1889836-A1 | NOVEL PYRIDINE DERIVATIVE AND PYRIMIDINE DERIVATIVE (3) | Eisai R&D Management Co., Ltd. (JP) | 2008-02-20 | — | — | EP | disclosed |