Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.42 |
| ▸ | MEN1 | O00255 | 4/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.39 |
| ▸ | HBB | P68871 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | PDE10A | Q9Y233 | 5/20 | 0.31 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.31 |
| ▸ | FEN1 | P39748 | 1/20 | 0.31 |
| ▸ | APAF1 | O14727 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL581231 | 0.92 | MEN1 (0.46) | KDM4EMEN1KMT2APOLBKEAP1 | |
| SCHEMBL4669545 | 0.82 | MEN1 (0.47) | MEN1KMT2AALDH1A1RAB9APDE10A | |
| SCHEMBL4234667 | 0.77 | KMT2A (0.58) | KDM4EMEN1KMT2APOLBKEAP1 | |
| SCHEMBL10271917 | 0.74 | KEAP1 (0.59) | KDM4EMEN1KMT2APOLBKEAP1 | |
| SCHEMBL122934 | 0.72 | — | — | |
| SCHEMBL29622282 | 0.72 | — | — | |
| SCHEMBL580112 | 0.71 | MEN1 (0.56) | MEN1KMT2AALDH1A1RAB9APDE10A | |
| SCHEMBL4230135 | 0.71 | KMT2A (0.58) | KDM4EMEN1KMT2APOLBKEAP1 | |
| SCHEMBL14434735 | 0.70 | KDM4E (0.46) | KDM4EMEN1KMT2APOLBKEAP1 | |
| SCHEMBL15914773 | 0.70 | KMT2A (0.66) | KDM4EMEN1KMT2APOLBKEAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1984353-A1 | AURORA KINASE MODULATORS AND METHOD OF USE | Amgen, Inc (US) | 2008-10-29 | — | — | EP | disclosed |
| WO-2007087276-A1 | AURORA KINASE MODULATORS AND METHOD OF USE | AMGEN INC. (US) | 2007-08-02 | — | — | WO | disclosed |