SCHEMBL580112

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

	Compound	similarity	top predicted	shared targets
	SCHEMBL4669545	0.91	MEN1 (0.47)	MEN1KMT2AAPAF1PDE10AMAPT
	SCHEMBL4008329	0.83	PDE10A (0.51)	MEN1KMT2APDE10AMAPTALDH1A1
	SCHEMBL31395515	0.82	PDE10A (0.53)	KMT2APDE10ACYP3A4DRD1SMN1; SMN2
	SCHEMBL20406612	0.82	PDE10A (0.48)	MEN1KMT2APDE10AMAPTALDH1A1
	SCHEMBL31395507	0.82	PDE10A (0.51)	MEN1KMT2APDE10ATDP1RAB9A
	SCHEMBL20406610	0.82	PDE10A (0.51)	MEN1KMT2APDE10ATDP1RAB9A
	SCHEMBL2488534	0.82	RAB9A (0.56)	MEN1KMT2APDE10AMAPTALDH1A1
	SCHEMBL7910614	0.82	KMT2A (0.59)	MEN1KMT2APDE10AMAPTALDH1A1
	SCHEMBL20406238	0.82	PDE10A (0.48)	MEN1KMT2APDE10AMAPTALDH1A1
	SCHEMBL20406087	0.81	MPO (0.43)	MEN1KMT2AAPAF1PDE10ARAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 54 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.