Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | APAF1 | O14727 | 1/20 | 0.47 |
| ▸ | PDE10A | Q9Y233 | 6/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | MAOA | P21397 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | DRD1 | P21728 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | MITF | O75030 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | GFER | P55789 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | NLRP1 | Q9C000 | 1/20 | 0.35 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.35 |
| ▸ | GCK | P35557 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL580112 | 0.91 | MEN1 (0.56) | MEN1KMT2AAPAF1PDE10ARAB9A | |
| SCHEMBL4667183 | 0.82 | KDM4E (0.42) | MEN1KMT2AAPAF1PDE10ARAB9A | |
| SCHEMBL2488534 | 0.81 | RAB9A (0.56) | MEN1KMT2APDE10ARAB9AMAPT | |
| SCHEMBL15044336 | 0.78 | MEN1 (0.56) | MEN1KMT2AAPAF1PDE10ARAB9A | |
| SCHEMBL1304578 | 0.77 | MAOA (0.50) | MEN1KMT2AAPAF1RAB9AMAOA | |
| SCHEMBL20406250 | 0.77 | PDE10A (0.45) | MEN1KMT2APDE10ARAB9ADRD1 | |
| SCHEMBL4008329 | 0.76 | PDE10A (0.51) | MEN1KMT2APDE10AMAPTDRD1 | |
| SCHEMBL122934 | 0.75 | — | — | |
| SCHEMBL29622282 | 0.75 | — | — | |
| SCHEMBL20406610 | 0.74 | PDE10A (0.51) | MEN1KMT2APDE10ARAB9ADRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1984353-A1 | AURORA KINASE MODULATORS AND METHOD OF USE | Amgen, Inc (US) | 2008-10-29 | — | — | EP | disclosed |
| WO-2007087276-A1 | AURORA KINASE MODULATORS AND METHOD OF USE | AMGEN INC. (US) | 2007-08-02 | — | — | WO | disclosed |