Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | IDO1 | P14902 | 1/20 | 0.52 |
| ▸ | KEAP1 | Q14145 | 2/20 | 0.50 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.50 |
| ▸ | TACR1 | P25103 | 1/20 | 0.49 |
| ▸ | CTSS | P25774 | 6/20 | 0.48 |
| ▸ | CTSL | P07711 | 5/20 | 0.48 |
| ▸ | CTSB | P07858 | 4/20 | 0.48 |
| ▸ | CTSK | P43235 | 3/20 | 0.48 |
| ▸ | TGM2 | P21980 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.46 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.45 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL534782 | 0.85 | LMNA (0.53) | LMNASMN1; SMN2HTTIDO1KEAP1 | |
| SCHEMBL6961214 | 0.82 | FFAR1 (0.57) | LMNASMN1; SMN2HTTKEAP1NFE2L2 | |
| SCHEMBL555531 | 0.82 | SMN1; SMN2 (0.50) | LMNASMN1; SMN2HTTIDO1KEAP1 | |
| Benzyl Phenethylcarbamate SCHEMBL27338403 | 0.81 | LMNA (0.61) | LMNASMN1; SMN2HTTKEAP1NFE2L2 | |
| SCHEMBL6746741 | 0.81 | LMNA (0.61) | LMNASMN1; SMN2HTTIDO1KEAP1 | |
| SCHEMBL4667297 | 0.81 | LMNA (0.61) | LMNASMN1; SMN2HTTIDO1KEAP1 | |
| SCHEMBL14357351 | 0.80 | ABCB1 (0.57) | LMNASMN1; SMN2HTTIDO1KEAP1 | |
| SCHEMBL19385640 | 0.80 | HIF1A (0.45) | L3MBTL1MAPTFFAR1 | |
| Benzyl Phenethylcarbamate SCHEMBL4287199 | 0.80 | LMNA (0.73) | LMNASMN1; SMN2HTTIDO1KEAP1 | |
| SCHEMBL535090 | 0.80 | LMNA (0.60) | LMNASMN1; SMN2HTTIDO1KEAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1928834-A1 | ALKYLNITRILE QUINOLINES, AS NK-3 RECEPTOR LIGANDS | AstraZeneca AB (SE) | 2008-06-11 | — | — | EP | disclosed |
| WO-2007035157-A1 | ALKYLNITRILE QUINOLINES, AS NK-3 RECEPTOR LIGANDS | ASTRAZENECA AB (SE) | 2007-03-29 | — | — | WO | disclosed |