Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | IDO1 | P14902 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | KEAP1 | Q14145 | 2/20 | 0.46 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | TGM2 | P21980 | 1/20 | 0.44 |
| ▸ | KCNA5 | P22460 | 2/20 | 0.42 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.42 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.42 |
| ▸ | CTSL | P07711 | 2/20 | 0.41 |
| ▸ | CTSB | P07858 | 2/20 | 0.41 |
| ▸ | CTSS | P25774 | 2/20 | 0.41 |
| ▸ | CTSK | P43235 | 2/20 | 0.41 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.41 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL534782 | 0.84 | LMNA (0.53) | SMN1; SMN2LMNAHTTIDO1L3MBTL1 | |
| SCHEMBL4667311 | 0.82 | LMNA (0.56) | SMN1; SMN2LMNAHTTIDO1L3MBTL1 | |
| SCHEMBL534744 | 0.80 | MTNR1A (0.51) | LMNAHTT | |
| SCHEMBL6746741 | 0.76 | LMNA (0.61) | SMN1; SMN2LMNAHTTIDO1L3MBTL1 | |
| SCHEMBL4667297 | 0.76 | LMNA (0.61) | SMN1; SMN2LMNAHTTIDO1L3MBTL1 | |
| Benzyl Phenethylcarbamate SCHEMBL4287199 | 0.75 | LMNA (0.73) | SMN1; SMN2LMNAHTTIDO1L3MBTL1 | |
| SCHEMBL535090 | 0.75 | LMNA (0.60) | SMN1; SMN2LMNAHTTIDO1L3MBTL1 | |
| SCHEMBL29682187 | 0.75 | LMNA (0.60) | SMN1; SMN2LMNAHTTIDO1L3MBTL1 | |
| SCHEMBL21848124 | 0.75 | LMNA (0.60) | SMN1; SMN2LMNAHTTIDO1L3MBTL1 | |
| SCHEMBL15769888 | 0.75 | HTT (0.44) | SMN1; SMN2LMNAHTTL3MBTL1KEAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120035214-A1 | RENIN INHIBITORS | MERCK CANADA INC. (CA) | 2012-02-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120035214-A1 | RENIN INHIBITORS | REN, ACE, AGTR1 | SMN1; SMN2 4604/4885LMNA 1880/4885HTT 4056/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.