Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA4 | P22748 | 1/20 | 0.38 |
| ▸ | TUBB1 | Q9H4B7 | 5/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.35 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.35 |
| ▸ | DBH | P09172 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.33 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.33 |
| ▸ | TUBB | P07437 | 1/20 | 0.33 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.33 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.33 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.33 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.33 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.33 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.33 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.33 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10986 | 0.95 | CA2 (0.41) | HSD17B10CA2CA4TUBB1MAPT | |
| SCHEMBL24252805 | 0.85 | HSD17B10 (0.35) | HSD17B10CA2CA4TUBB1MAPT | |
| SCHEMBL17875684 | 0.84 | HSD17B10 (0.50) | HSD17B10CA2CA4TUBB1MAPT | |
| SCHEMBL26927713 | 0.82 | ALOX15 (0.47) | CA2CA4TUBB1MAPTALOX15 | |
| SCHEMBL930657 | 0.82 | KDM4E (0.40) | HSD17B10CA2CA4TUBB1MAPT | |
| SCHEMBL31500460 | 0.82 | ALOX15 (0.47) | CA2CA4TUBB1MAPTALOX15 | |
| SCHEMBL2309487 | 0.80 | POLB (0.38) | HSD17B10CA2CA4TUBB1MAPT | |
| SCHEMBL15271622 | 0.80 | ACLY (0.41) | HSD17B10CA2CA4TUBB1MAPT | |
| SCHEMBL16596078 | 0.80 | TDP1 (0.46) | HSD17B10CA2CA4TUBB1MAPT | |
| SCHEMBL31190021 | 0.80 | POLB (0.38) | HSD17B10CA2CA4TUBB1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1893619-A1 | NEW OXABISPIDINE COMPOUNDS FOR THE TREATMENT OF CARDIAC ARRHYTMIAS | AstraZeneca AB (SE) | 2008-03-05 | — | — | EP | disclosed |
| WO-2006135316-A1 | New oxabispidine compounds for the treatment of cardiac arrhythmias | ASTRAZENECA AB (SE) | 2006-12-21 | — | — | WO | disclosed |