Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 6/20 | 0.46 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.38 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.38 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.38 |
| ▸ | SGK1 | O00141 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | PIM1 | P11309 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.37 |
| ▸ | ACP1 | P24666 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4668220 | 1.00 | ALOX5 (0.46) | ALOX5AKR1B1AKR1C3AKR1C2SGK1 | |
| SCHEMBL4143920 | 0.87 | PTGS2 (0.49) | ALOX5MEN1KMT2AHTTALDH1A1 | |
| SCHEMBL4143915 | 0.87 | PTGS2 (0.49) | ALOX5MEN1KMT2AHTTALDH1A1 | |
| SCHEMBL27739331 | 0.85 | ALOX5 (0.46) | ALOX5MEN1KMT2APIM1RAB9A | |
| Acetic Acid SCHEMBL4132772 | 0.84 | ALOX5 (0.47) | ALOX5AKR1B1MEN1KMT2APIM1 | |
| Acetic Acid SCHEMBL4132773 | 0.84 | ALOX5 (0.47) | ALOX5AKR1B1MEN1KMT2APIM1 | |
| SCHEMBL4127367 | 0.82 | ALOX5 (0.51) | ALOX5MEN1KMT2APIM1RAB9A | |
| SCHEMBL4127370 | 0.82 | ALOX5 (0.51) | ALOX5MEN1KMT2APIM1RAB9A | |
| SCHEMBL4140263 | 0.82 | ALOX5 (0.47) | ALOX5AKR1B1MEN1KMT2APIM1 | |
| SCHEMBL4140267 | 0.82 | ALOX5 (0.47) | ALOX5AKR1B1MEN1KMT2APIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101268060-A | Thiazolinone and oxazolinone compounds and application thereof as PTP1B inhibitor | TORRENT PHARMACEUTICALS LTD (IN) | 2008-09-17 | — | — | CN | claimed |
| EP-1934192-A1 | THIAZOLINONES AND OXAZOLINONES AND THEIR USE AS PTP1B INHIBITORS | Torrent Pharmaceuticals Ltd (IN) | 2008-06-25 | — | — | EP | claimed |
| WO-2007032028-A1 | THIAZOLINONES AND OXAZOLINONES AND THEIR USE AS PTP1B INHIBITORS | TORRENT PHARMACEUTICALS LTD. (IN) | 2007-03-22 | — | — | WO | claimed |
| CN-101268060-A | Thiazolinone and oxazolinone compounds and application thereof as PTP1B inhibitor | TORRENT PHARMACEUTICALS LTD (IN) | 2008-09-17 | — | — | CN | disclosed |