Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 3/20 | 0.37 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.37 |
| ▸ | TPX2 | Q9ULW0 | 3/20 | 0.37 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.34 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.34 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.34 |
| ▸ | PDE10A | Q9Y233 | 4/20 | 0.33 |
| ▸ | TEK | Q02763 | 1/20 | 0.33 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4668332 | 0.85 | AURKB (0.36) | AURKAAURKBTPX2PDE10ATEK | |
| SCHEMBL4668256 | 0.80 | AURKA (0.38) | AURKAAURKBTPX2MAPK13MAPK12 | |
| SCHEMBL4667173 | 0.79 | AURKB (0.46) | AURKAAURKBTPX2TEK | |
| SCHEMBL4667140 | 0.79 | PDE10A (0.43) | PDE10ATEK | |
| SCHEMBL4668267 | 0.77 | TEK (0.46) | AURKAAURKBTPX2TEK | |
| SCHEMBL580553 | 0.76 | LTA4H (0.36) | AURKAAURKBMAPK14 | |
| SCHEMBL581299 | 0.74 | TEK (0.42) | AURKAAURKBTPX2MAPK14TEK | |
| SCHEMBL581233 | 0.74 | AURKB (0.41) | AURKAAURKBTPX2MAPK14PDE10A | |
| SCHEMBL4668273 | 0.73 | AURKB (0.48) | AURKAAURKBTPX2TEK | |
| SCHEMBL4668531 | 0.71 | TEK (0.41) | AURKAAURKBTPX2TEK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1984353-A1 | AURORA KINASE MODULATORS AND METHOD OF USE | Amgen, Inc (US) | 2008-10-29 | — | — | EP | disclosed |
| WO-2007087276-A1 | AURORA KINASE MODULATORS AND METHOD OF USE | AMGEN INC. (US) | 2007-08-02 | — | — | WO | disclosed |