Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 1/20 | 0.36 |
| ▸ | PDE10A | Q9Y233 | 5/20 | 0.36 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.33 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | CRHBP | P24387 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4668530 | 0.86 | USP2 (0.31) | BTKCYP1A2CYP2C19NPC1RAB9A | |
| SCHEMBL4667120 | 0.77 | AXL (0.33) | BTKPDE10A | |
| SCHEMBL4794734 | 0.75 | FEN1 (0.35) | PDE10ANPC1MAPTRAB9A | |
| SCHEMBL4668256 | 0.75 | AURKA (0.38) | PDE10AALDH1A1MAPT | |
| SCHEMBL4428347 | 0.68 | MEN1 (0.46) | MEN1KMT2AL3MBTL1NPC1MAPT | |
| SCHEMBL4782599 | 0.65 | AURKA (0.44) | PDE10AALDH1A1 | |
| SCHEMBL1834038 | 0.64 | NPC1 (0.31) | MEN1KMT2ANPC1RAB9A | |
| SCHEMBL31272745 | 0.64 | PDE10A (0.58) | PDE10AMEN1ALDH1A1KMT2ACYP1A2 | |
| SCHEMBL581019 | 0.63 | AURKA (0.58) | MAPT | |
| SCHEMBL4668281 | 0.63 | USP2 (0.31) | CYP1A2CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1984353-A1 | AURORA KINASE MODULATORS AND METHOD OF USE | Amgen, Inc (US) | 2008-10-29 | — | — | EP | disclosed |
| WO-2007087276-A1 | AURORA KINASE MODULATORS AND METHOD OF USE | AMGEN INC. (US) | 2007-08-02 | — | — | WO | disclosed |