⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18824851 | 1.00 | — | — | |
| Hydrochloric Acid SCHEMBL3507710 | 0.97 | ALDH1A1 (0.39) | — | |
| Water SCHEMBL7767504 | 0.97 | ALDH1A1 (0.39) | — | |
| Ether SCHEMBL7767502 | 0.84 | GABRP (0.35) | — | |
| SCHEMBL12682066 | 0.77 | — | — | |
| SCHEMBL7353061 | 0.77 | ALDH1A1 (0.40) | — | |
| SCHEMBL8143838 | 0.77 | — | — | |
| SCHEMBL3675810 | 0.77 | — | — | |
| SCHEMBL28777366 | 0.76 | ALDH1A1 (0.36) | — | |
| Hydrochloric Acid SCHEMBL7839238 | 0.76 | SLC7A5 (0.40) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 46 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-3887756-B2 | — | — | 2007-02-28 | — | — | JP | claimed |
| EP-0842153-A1 | METHOD OF PREPARING NORBENZOMORPHANE AS AN INTERMEDIATE IN THE PREPARATION OF PHARMACEUTICALLY USEFUL BENZOMORPHANE DERIVATIVES, IN PARTICULAR (-)-(1R,5S,2\"R)-3'-HYDROXY-2-(2-METHOXYPROPYL)-5,9,9-TRIMETHYL-6,7-BENZOMORPHANE | BOEHRINGER INGELHEIM KG (DE) | 1998-05-20 | — | — | EP | claimed |
| WO-1997006146-A1 | METHOD OF PREPARING NORBENZOMORPHANE AS AN INTERMEDIATE IN THE PREPARATION OF PHARMACEUTICALLY USEFUL BENZOMORPHANE DERIVATIVES, IN PARTICULAR (-)-(1R,5S,2'R)-3'-HYDROXY-2-(2-METHOXYPROPYL)-5,9,9-TRIMETHYL-6,7-BENZOMORPHANE | BOEHRINGER INGELHEIM KG (DE) | 1997-02-20 | — | — | WO | claimed |
| US-20250376709-A1 | PAPB AS A BIMOIETY-DEPENDENT THIOETHER INSTALLATION TOOL | UNIV UTAH RES FOUND (US) | 2025-12-11 | — | — | US | disclosed |
| WO-2025085727-A1 | PAPB AS A BIMOIETY-DEPENDENT THIOETHER INSTALLATION TOOL | BANDARIAN VAHE (US) | 2025-04-24 | — | — | WO | disclosed |
| EP-4508235-A2 | PAPB AS A BIMOIETY-DEPENDENT THIOETHER INSTALLATION TOOL | University of Utah Research Foundation (US) | 2025-02-19 | — | — | EP | disclosed |
| CN-113993861-B | Phenyl ethers and anilines of pyrazolyl-amino-pyrimidinyl derivatives, compositions and methods thereof | 凌科药业(杭州)有限公司 | 2024-05-14 | — | — | CN | disclosed |
| WO-2023201372-A2 | PAPB AS A BIMOIETY-DEPENDENT THIOETHER INSTALLATION TOOL | UNIVERSITY OF UTAH RESEARCH FOUNDATION (US) | 2023-10-19 | — | — | WO | disclosed |
| CN-109369635-B | Compound or pharmaceutically acceptable salt thereof, application thereof and pharmaceutical composition | 赛克里翁治疗有限公司 | 2023-06-30 | — | — | CN | disclosed |
| CN-109384778-B | Use of a compound or a pharmaceutically acceptable salt thereof for the manufacture of a medicament for the treatment of a disease, health condition or disorder | 赛克里翁治疗有限公司 | 2022-12-13 | — | — | CN | disclosed |
| CN-110016020-B | Compound or pharmaceutically acceptable salt thereof, application and pharmaceutical composition thereof | 赛克里翁治疗有限公司 | 2022-07-26 | — | — | CN | disclosed |
| US-6136980-A | Method of preparing norbenzomorphane as an intermediate in the preparation of pharmaceutically useful benzomorphane derivatives, in particular (-)-(1R,5S,2\"R)-3'-hydroxy-2-(2-methoxypropyl)-5,9,9-trimethyl-6,7-benzo morphane | BOEHRINGER INGELHEIM KG (DE) | 2000-10-24 | — | — | US | disclosed |
| US-6054604-A | Method of preparing norbenzomorphane as an intermediate | BOEHRINGER INGELHEIM KG (DE) | 2000-04-25 | — | — | US | disclosed |
| US-5945535-A | Method of preparing norbenzomorphanes | BOEHRINGER INGELHEIM KG (DE) | 1999-08-31 | — | — | US | disclosed |
| CN-1224417-A | Fused isoindolones as inhibitors of protein kinase C | CEPHALON INC (US) | 1999-07-28 | — | — | CN | disclosed |
| EP-0885288-A1 | BODY SOAP COMPOSITION | Johnson & Johnson Kabushiki Kaisha (JP) | 1998-12-23 | — | — | EP | disclosed |
| US-5808060-A | Fused isoindolones | CEPHALON, INC. (US) | 1998-09-15 | — | — | US | disclosed |
| WO-1997027279-A1 | BODY SOAP COMPOSITION | JOHNSON & JOHNSON KABUSHIKI KAISHA (JP) | 1997-07-31 | — | — | WO | disclosed |
| US-5302730-A | Acylation with acetic acid at positions one and seven; eliminating acyl group at position seven by solvolysis | NIPPON KAYAKU KK (JP) | 1994-04-12 | — | — | US | disclosed |
| EP-0297496-A2 | Novel process for the preparation of 6,7-Diacyl-7-deacetylforskolin derivatives | NIPPON KAYAKU KABUSHIKI KAISHA (JP) | 1989-01-04 | — | — | EP | disclosed |