Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | CTRC | Q99895 | 1/20 | 0.37 |
| ▸ | TYR | P14679 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.36 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.36 |
| ▸ | GABRP | O00591 | 1/20 | 0.36 |
| ▸ | GABRD | O14764 | 1/20 | 0.36 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.36 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.36 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.36 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.36 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.36 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30758065 | 0.89 | ALOX5 (0.40) | ALDH1A1HPGDHSD17B10ALOX5KDM4E | |
| SCHEMBL8469336 | 0.87 | ALOX5 (0.38) | ALDH1A1HPGDHSD17B10ALOX5KDM4E | |
| SCHEMBL38650932 | 0.87 | ALOX5 (0.38) | ALDH1A1HPGDHSD17B10ALOX5KDM4E | |
| SCHEMBL38650817 | 0.87 | ALOX5 (0.38) | ALDH1A1HPGDHSD17B10ALOX5KDM4E | |
| SCHEMBL18598999 | 0.84 | CTRC (0.38) | ALDH1A1HPGDHSD17B10CTRCTYR | |
| SCHEMBL11575458 | 0.84 | KMT2A (0.49) | ALDH1A1HPGDHSD17B10KDM4EMAPT | |
| SCHEMBL2303604 | 0.81 | AGTR1 (0.37) | ALDH1A1HPGDHSD17B10ALOX5CTRC | |
| SCHEMBL8578166 | 0.81 | BID (0.41) | ALDH1A1ALOX5TYRKDM4EMAPT | |
| SCHEMBL23531063 | 0.80 | ALOX5 (0.38) | ALDH1A1HSD17B10ALOX5KDM4EMAPT | |
| SCHEMBL4726562 | 0.78 | BID (0.49) | ALDH1A1HSD17B10KDM4EMAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1984353-A1 | AURORA KINASE MODULATORS AND METHOD OF USE | Amgen, Inc (US) | 2008-10-29 | — | — | EP | disclosed |
| WO-2007087276-A1 | AURORA KINASE MODULATORS AND METHOD OF USE | AMGEN INC. (US) | 2007-08-02 | — | — | WO | disclosed |