SCHEMBL4668382

SCHEMBL4668382

NC(=O)c1cccc2c1Oc1ccccc1C2

nearest known ligand 0.53

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
PARP1 P09874 7/20 0.53
TRPA1 O75762 3/20 0.51
MAOA P21397 1/20 0.50
MAOB P27338 1/20 0.50
MAPT P10636 3/20 0.40
TP53 P04637 1/20 0.40
SMN1; SMN2 Q16637 1/20 0.40
AURKA O14965 1/20 0.40
KDM4E B2RXH2 2/20 0.39
ALDH1A1 P00352 2/20 0.39
HPGD P15428 2/20 0.39
TSHR P16473 1/20 0.39
HSD17B10 Q99714 1/20 0.39
HTR2B P41595 1/20 0.38
CYP2C9 P11712 1/20 0.38
CYP11B1 P15538 1/20 0.38
CYP11B2 P19099 1/20 0.38
LMNA P02545 1/20 0.37
METAP2 P50579 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31069904 0.86 MAOA (0.48) PARP1TRPA1MAOAMAOBKDM4E
SCHEMBL7325719 0.85 MAOA (0.52) TRPA1MAOAMAOBMAPTSMN1; SMN2
SCHEMBL4668365 0.84 MAOA (0.50) PARP1TRPA1MAOAMAOBSMN1; SMN2
SCHEMBL8961832 0.83 MAOA (0.48) PARP1TRPA1MAOAMAOBCYP2C9
SCHEMBL4777607 0.81 MAOA (0.47) PARP1TRPA1MAOAMAOBMAPT
SCHEMBL7554503 0.81 TRPA1 (0.50) PARP1TRPA1MAOAMAOBMAPT
SCHEMBL13098147 0.78 GAA (0.54) PARP1TRPA1MAPTTP53SMN1; SMN2
SCHEMBL6427706 0.78 TRPA1 (0.58) PARP1TRPA1MAPTKDM4EALDH1A1
SCHEMBL4777601 0.75 MAOA (0.47) MAOAMAOB
SCHEMBL13777196 0.74 MAOA (0.73) MAOAMAOBMAPTSMN1; SMN2KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-101243079-A Tricyclic opioid modulators JANSSEN PHARMACEUTICA NV (BE) 2008-08-13 CN disclosed
EP-1896467-A2 TRICYCLIC OPIOID MODULATORS JANSSEN PHARMACEUTICA N.V. (BE) 2008-03-12 EP disclosed
WO-2006138528-A2 TRICYCLIC OPIOID MODULATORS JANSSEN PHARMACEUTICA N.V (BE) 2006-12-28 WO disclosed
US-5741715-A FLUORESCENT POLARIZATION IMMUNOASSAY ROCHE DIAGNOSTIC SYSTEMS, INC. (US) 1998-04-21 US disclosed