Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FEN1 | P39748 | 8/20 | 0.33 |
| ▸ | ALOX5AP | P20292 | 5/20 | 0.33 |
| ▸ | BTK | Q06187 | 1/20 | 0.32 |
| ▸ | MET | P08581 | 1/20 | 0.32 |
| ▸ | NFATC1 | O95644 | 1/20 | 0.31 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.31 |
| ▸ | GRM5 | P41594 | 1/20 | 0.31 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.31 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.31 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.31 |
| ▸ | CCNC | P24863 | 1/20 | 0.31 |
| ▸ | CDK8 | P49336 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4667120 | 0.79 | AXL (0.33) | BTKMETNFATC1DYRK1AGRM5 | |
| SCHEMBL4442004 | 0.72 | CCNC (0.46) | BTKMETCCNCCDK8 | |
| SCHEMBL4441986 | 0.67 | MEN1 (0.45) | — | |
| SCHEMBL4668233 | 0.67 | AURKA (0.37) | PDE10A | |
| SCHEMBL581802 | 0.66 | AURKA (0.48) | MET | |
| SCHEMBL1894762 | 0.63 | NCOA1 (0.66) | BTKNCOA1NCOA3 | |
| SCHEMBL14165630 | 0.63 | BTK (0.51) | BTKNCOA1NCOA3 | |
| SCHEMBL14165320 | 0.60 | BTK (0.48) | BTK | |
| SCHEMBL29421428 | 0.59 | FEN1 (0.54) | FEN1 | |
| SCHEMBL14165886 | 0.58 | NCOA1 (0.58) | BTKNCOA1NCOA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1984353-A1 | AURORA KINASE MODULATORS AND METHOD OF USE | Amgen, Inc (US) | 2008-10-29 | — | — | EP | disclosed |
| WO-2007087276-A1 | AURORA KINASE MODULATORS AND METHOD OF USE | AMGEN INC. (US) | 2007-08-02 | — | — | WO | disclosed |