Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | OXTR | P30559 | 7/20 | 0.42 |
| ▸ | AVPR1A | P37288 | 6/20 | 0.42 |
| ▸ | AVPR2 | P30518 | 2/20 | 0.42 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.39 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | CCKBR | P32239 | 1/20 | 0.37 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4428347 | 0.72 | MEN1 (0.46) | MEN1KMT2AOXTRAVPR1AAVPR2 | |
| SCHEMBL31439068 | 0.64 | NR1H3 (0.50) | MEN1KMT2AOXTRAVPR1AAVPR2 | |
| SCHEMBL11619876 | 0.64 | NR1H3 (0.50) | MEN1KMT2AOXTRAVPR1AAVPR2 | |
| SCHEMBL1422182 | 0.63 | HSD17B1 (0.67) | MEN1KMT2AOXTRKDRMAPT | |
| SCHEMBL577613 | 0.62 | HSD17B1 (0.49) | MEN1KMT2AOXTRKDRL3MBTL1 | |
| SCHEMBL13575392 | 0.61 | L3MBTL1 (0.60) | OXTRAVPR1AAVPR2JAK2L3MBTL1 | |
| SCHEMBL4477596 | 0.60 | PTGS2 (0.57) | MEN1KMT2A | |
| SCHEMBL17004637 | 0.60 | KDR (0.40) | MEN1KMT2AOXTRAVPR1AAVPR2 | |
| SCHEMBL21397330 | 0.60 | CHRNB2 (0.59) | OXTRAVPR1ACHRNB2CHRNA4 | |
| SCHEMBL27657899 | 0.59 | BRD4 (0.38) | OXTRAVPR1AAVPR2JAK2L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2137177-A2 | AURORA KINASE MODULATORS AND METHOD OF USE | Amgen, Inc (US) | 2009-12-30 | — | — | EP | disclosed |
| WO-2008124083-A2 | AURORA KINASE MODULATORS AND METHOD OF USE | AMGEN INC. (US) | 2008-10-16 | — | — | WO | disclosed |