Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNC | P24863 | 4/20 | 0.46 |
| ▸ | CDK8 | P49336 | 4/20 | 0.46 |
| ▸ | MET | P08581 | 1/20 | 0.40 |
| ▸ | PRKDC | P78527 | 5/20 | 0.37 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.37 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.36 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.36 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | ACVR1B | P36896 | 1/20 | 0.35 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.35 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.35 |
| ▸ | BMPR2 | Q13873 | 1/20 | 0.35 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4668540 | 0.72 | FEN1 (0.33) | CCNCCDK8METBTK | |
| SCHEMBL4438797 | 0.72 | KCNH2 (0.40) | METALKGRM4 | |
| SCHEMBL2207786 | 0.70 | KDR (0.48) | CCNCCDK8SLC2A1KDRKDM4E | |
| SCHEMBL4434315 | 0.66 | MET (0.34) | METGRM4KDR | |
| SCHEMBL4442343 | 0.66 | FGFR2 (0.37) | CCNCCDK8METALKKDR | |
| SCHEMBL4668233 | 0.65 | AURKA (0.37) | KDM4EALDH1A1MAPTHPGD | |
| SCHEMBL20887646 | 0.64 | CCNC (1.00) | CCNCCDK8PLK4 | |
| SCHEMBL2210999 | 0.64 | CCNC (0.49) | CCNCCDK8SLC2A1KDRKDM4E | |
| SCHEMBL33377163 | 0.63 | PRKDC (0.56) | CCNCCDK8PRKDCSLC2A1ACVR1 | |
| SCHEMBL4441986 | 0.63 | MEN1 (0.45) | KDRALDH1A1MAPTHPGDTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2137177-A2 | AURORA KINASE MODULATORS AND METHOD OF USE | Amgen, Inc (US) | 2009-12-30 | — | — | EP | disclosed |
| WO-2008124083-A2 | AURORA KINASE MODULATORS AND METHOD OF USE | AMGEN INC. (US) | 2008-10-16 | — | — | WO | disclosed |