Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | OXTR | P30559 | 8/20 | 0.41 |
| ▸ | AVPR1A | P37288 | 7/20 | 0.41 |
| ▸ | AVPR2 | P30518 | 2/20 | 0.41 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.39 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | CCKBR | P32239 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.35 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4441986 | 0.72 | MEN1 (0.45) | MEN1KMT2AOXTRAVPR1AAVPR2 | |
| SCHEMBL4668530 | 0.69 | USP2 (0.31) | NPC1PKMRAB9AUSP2 | |
| SCHEMBL4668559 | 0.68 | BTK (0.36) | MEN1KMT2ANPC1RAB9AL3MBTL1 | |
| SCHEMBL31439068 | 0.65 | NR1H3 (0.50) | MEN1KMT2AOXTRAVPR1AAVPR2 | |
| SCHEMBL11619876 | 0.65 | NR1H3 (0.50) | MEN1KMT2AOXTRAVPR1AAVPR2 | |
| SCHEMBL1422182 | 0.64 | HSD17B1 (0.67) | MEN1KMT2AOXTRKDRNPC1 | |
| SCHEMBL577613 | 0.63 | HSD17B1 (0.49) | MEN1KMT2AOXTRKDRNPC1 | |
| SCHEMBL29092646 | 0.62 | OPRM1 (0.47) | MEN1KMT2ACHRNB2CHRNA4SLC6A2 | |
| SCHEMBL29872335 | 0.62 | MEN1 (0.53) | MEN1KMT2ANPC1PKMRAB9A | |
| SCHEMBL4477596 | 0.61 | PTGS2 (0.57) | MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2137177-A2 | AURORA KINASE MODULATORS AND METHOD OF USE | Amgen, Inc (US) | 2009-12-30 | — | — | EP | disclosed |
| WO-2008124083-A2 | AURORA KINASE MODULATORS AND METHOD OF USE | AMGEN INC. (US) | 2008-10-16 | — | — | WO | disclosed |