Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4668530 | 0.76 | USP2 (0.31) | USP2CYP1A2CYP3A4CYP2D6MAPK1 | |
| SCHEMBL4668540 | 0.72 | FEN1 (0.33) | — | |
| SCHEMBL4441986 | 0.71 | MEN1 (0.45) | — | |
| SCHEMBL4668233 | 0.71 | AURKA (0.37) | — | |
| SCHEMBL4668332 | 0.70 | AURKB (0.36) | CYP1A2CYP3A4CYP2C19 | |
| SCHEMBL4667173 | 0.65 | AURKB (0.46) | — | |
| SCHEMBL4668559 | 0.63 | BTK (0.36) | CYP1A2CYP2C19 | |
| SCHEMBL20406329 | 0.62 | CYP2C9 (0.43) | CYP1A2CYP3A4CYP2D6MAPK1CYP2C19 | |
| SCHEMBL20406283 | 0.59 | KDM4E (0.49) | — | |
| SCHEMBL20406228 | 0.59 | EGFR (0.42) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1984353-A1 | AURORA KINASE MODULATORS AND METHOD OF USE | Amgen, Inc (US) | 2008-10-29 | — | — | EP | disclosed |
| WO-2007087276-A1 | AURORA KINASE MODULATORS AND METHOD OF USE | AMGEN INC. (US) | 2007-08-02 | — | — | WO | disclosed |