Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | APP | P05067 | 1/20 | 0.35 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.34 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.34 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.33 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL4670894 | 0.98 | POLB (0.34) | POLBAPPCHRNB2CHRNA4CHRNA3 | |
| SCHEMBL4824088 | 0.84 | MEN1 (0.39) | POLBMEN1ALDH1A1LMNAKMT2A | |
| SCHEMBL4672795 | 0.80 | MEN1 (0.34) | CHRNB2CHRNA4CHRNA3CHRNA7MEN1 | |
| SCHEMBL5209363 | 0.77 | MAPT (0.40) | POLBAPPMEN1ALDH1A1LMNA | |
| Hydrochloric Acid SCHEMBL4818628 | 0.77 | ALDH1A1 (0.44) | MEN1ALDH1A1LMNAKMT2A | |
| SCHEMBL3817147 | 0.75 | MAPT (0.46) | POLBMEN1ALDH1A1LMNAKMT2A | |
| SCHEMBL4824084 | 0.74 | KMT2A (0.38) | MEN1ALDH1A1LMNAKMT2AMAPT | |
| SCHEMBL16585884 | 0.73 | MAPT (0.35) | POLBAPPCHRNB2CHRNA4CHRNA7 | |
| SCHEMBL4670942 | 0.73 | MAPT (0.34) | MEN1ALDH1A1LMNAKMT2AMAPT | |
| SCHEMBL7865566 | 0.73 | MAPT (0.40) | POLBMEN1ALDH1A1LMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1757586-B1 | POLYSBUSTITUIRTE 1,1-PYRIDINYLAMINOCYCLOPROPANAMIN DERIVATE, VERFAHREN ZU DEREN HERSTELLUNG UND DIESE ENTHALTENDE PHARMATUETISCHE ZUSAMMENSETZUNG | SERVIER LAB (FR) | 2008-12-03 | — | — | EP | disclosed |
| EP-1757586-A1 | POLYSBUSTITUIRTE 1,1-PYRIDINYLAMINOCYCLOPROPANAMIN DERIVATE, VERFAHREN ZU DEREN HERSTELLUNG UND DIESE ENTHALTENDE PHARMATUETISCHE ZUSAMMENSETZUNG | Les Laboratoires Servier (FR) | 2007-02-28 | — | — | EP | disclosed |