Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.43 |
| ▸ | RELA | Q04206 | 2/20 | 0.43 |
| ▸ | HSD11B1 | P28845 | 4/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.37 |
| ▸ | AXL | P30530 | 1/20 | 0.36 |
| ▸ | BACE1 | P56817 | 1/20 | 0.36 |
| ▸ | IDO1 | P14902 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.35 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.35 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4668551 | 0.84 | SMN1; SMN2 (0.46) | SMN1; SMN2NPC1NFKB1RAB9ANFKB2 | |
| SCHEMBL14600999 | 0.76 | FABP4 (0.44) | NTRK1CAPN1NR1H2NR1H3 | |
| SCHEMBL14600998 | 0.74 | DHODH (0.46) | NTRK1LMNA | |
| SCHEMBL14600469 | 0.74 | NTRK1 (0.44) | NTRK1P2RX7CAPN1 | |
| SCHEMBL4666864 | 0.74 | SMN1; SMN2 (0.45) | SMN1; SMN2NPC1NFKB1RAB9ANFKB2 | |
| SCHEMBL14601001 | 0.74 | NTRK1 (0.40) | L3MBTL1NTRK1KDM4EP2RX7CAPN1 | |
| SCHEMBL14601002 | 0.74 | MPO (0.40) | NTRK1CAPN1MEN1LMNAKMT2A | |
| SCHEMBL4667077 | 0.73 | NTRK1 (0.38) | HSD11B1ALDH1A1NTRK1CAPN1LMNA | |
| SCHEMBL14601000 | 0.73 | IGF2BP2 (0.39) | NTRK1 | |
| SCHEMBL4667857 | 0.71 | DHODH (0.42) | NTRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1928455-A1 | ANILINOPYRAZOLE DERIVATIVES USEFUL FOR THE TREATMENT OF DIABETES | Bayer Healthcare, LLC (US) | 2008-06-11 | — | — | EP | disclosed |
| WO-2007027842-A1 | ANILINOPYRAZOLE DERIVATIVES USEFUL FOR THE TREATMENT OF DIABETES | BAYER HEALTHCARE LLC (US) | 2007-03-08 | — | — | WO | disclosed |