Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 4/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | MITF | O75030 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | XBP1 | P17861 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.44 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL985355 | 0.89 | TSHR (0.58) | SMN1; SMN2TRPV1MEN1KMT2ATSHR | |
| SCHEMBL4671224 | 0.85 | MTNR1B (0.49) | SMN1; SMN2TRPV1MEN1KMT2ATSHR | |
| SCHEMBL986456 | 0.84 | EDNRA (0.49) | SMN1; SMN2TRPV1MEN1KMT2ATSHR | |
| SCHEMBL4669565 | 0.82 | TSHR (0.53) | SMN1; SMN2TRPV1MEN1KMT2ATSHR | |
| SCHEMBL986756 | 0.81 | PARP1 (0.45) | SMN1; SMN2TRPV1MEN1KMT2ATSHR | |
| SCHEMBL4674467 | 0.79 | MTNR1B (0.54) | MEN1KMT2ATSHRMTNR1B | |
| SCHEMBL987520 | 0.78 | MEN1 (0.45) | SMN1; SMN2TRPV1MEN1KMT2ATSHR | |
| SCHEMBL985851 | 0.76 | MTNR1B (0.56) | SMN1; SMN2MEN1KMT2ATSHRMTNR1B | |
| SCHEMBL985807 | 0.75 | TSHR (0.47) | SMN1; SMN2TRPV1MEN1KMT2ATSHR | |
| SCHEMBL986059 | 0.75 | TRPV1 (0.42) | SMN1; SMN2TRPV1MEN1KMT2ATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1732898-B1 | TETRAHYDROISOQUINOLINE- AND TETRAHYDROBENZAZEPINE DERIVATIVES AS IGF-1R INHIBITORS | ANALYTECON SA (CH) | 2008-01-23 | — | — | EP | disclosed |