Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 14/20 | 0.57 |
| ▸ | GPR84 | Q9NQS5 | 3/20 | 0.49 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5774556 | 0.92 | ACHE (0.60) | ACHEGPR84FFAR1 | |
| SCHEMBL2486968 | 0.83 | NPC1 (0.55) | ACHEGPR84NPC1LMNARAB9A | |
| SCHEMBL3180968 | 0.83 | GPR84 (0.41) | ACHEGPR84FFAR1 | |
| SCHEMBL3400197 | 0.79 | ACHE (0.60) | ACHE | |
| SCHEMBL8381680 | 0.79 | ACHE (0.74) | ACHE | |
| SCHEMBL10939707 | 0.79 | ACHE (0.81) | ACHE | |
| SCHEMBL3975468 | 0.79 | ACHE (0.88) | ACHE | |
| SCHEMBL7569673 | 0.79 | ACHE (0.81) | ACHE | |
| SCHEMBL3661888 | 0.78 | ACHE (0.54) | ACHE | |
| SCHEMBL6247952 | 0.78 | ACHE (0.58) | ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2001876-A2 | 8-AZABICYCLOÝ3.2.1¨OCTANE COMPOUNDS AS MU OPIOID RECEPTOR ANTAGONISTS | Theravance, Inc. (US) | 2008-12-17 | — | — | EP | disclosed |
| WO-2007103187-A2 | 8-AZABICYCLO[3.2.1]OCTANE COMPOUNDS AS MU OPIOID RECEPTOR ANTAGONISTS | THERAVANCE, INC. (US) | 2007-09-13 | — | — | WO | disclosed |