Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 14/20 | 0.60 |
| ▸ | GPR84 | Q9NQS5 | 3/20 | 0.51 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.51 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4669848 | 0.92 | ACHE (0.57) | ACHEGPR84FFAR1 | |
| SCHEMBL4820433 | 0.85 | GPR84 (0.47) | ACHEGPR84FFAR1 | |
| SCHEMBL4820417 | 0.85 | GPR84 (0.47) | ACHEGPR84FFAR1 | |
| SCHEMBL3400197 | 0.84 | ACHE (0.60) | ACHEEPHX2 | |
| SCHEMBL6247952 | 0.83 | ACHE (0.58) | ACHEEPHX2 | |
| SCHEMBL2486968 | 0.82 | NPC1 (0.55) | ACHEGPR84 | |
| SCHEMBL10939707 | 0.81 | ACHE (0.81) | ACHEEPHX2 | |
| SCHEMBL7569673 | 0.81 | ACHE (0.81) | ACHEEPHX2 | |
| SCHEMBL3975468 | 0.81 | ACHE (0.88) | ACHEEPHX2 | |
| SCHEMBL473236 | 0.79 | ACHE (0.85) | ACHEEPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1682524-A1 | NOVEL KETO-OXADIAZOLE DERIVATIVES AS CATHEPSIN INHIBITORS | Aventis Pharmaceuticals, Inc. (US) | 2006-07-26 | — | — | EP | disclosed |
| WO-2005040142-A9 | NOVEL KETO-OXADIAZOLE DERIVATIVES AS CATHEPSIN INHIBITORS | AVENTIS PHARMA INC (US) | 2005-06-09 | — | — | WO | disclosed |
| WO-2005040142-A1 | NOVEL KETO-OXADIAZOLE DERIVATIVES AS CATHEPSIN INHIBITORS | AVENTIS PHARMACEUTICALS INC. (US) | 2005-05-06 | — | — | WO | disclosed |