Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 4/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.36 |
| ▸ | P2RX4 | Q99571 | 2/20 | 0.35 |
| ▸ | REN | P00797 | 1/20 | 0.34 |
| ▸ | CHRM2 | P08172 | 4/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 4/20 | 0.33 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | PPARG | P37231 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4667739 | 0.83 | CYP4F2 (0.39) | ALOX5L3MBTL1P2RX4RENCHRM2 | |
| SCHEMBL4669426 | 0.82 | KMT2A (0.41) | ALOX5P2RX4RENTSHR | |
| SCHEMBL4667732 | 0.82 | REN (0.48) | ALOX5L3MBTL1P2RX4RENCHRM2 | |
| SCHEMBL4669425 | 0.80 | MEN1 (0.47) | ALOX5P2RX4RENCHRM2CHRM1 | |
| Bromide SCHEMBL11067184 | 0.79 | ALOX5 (0.38) | ALOX5L3MBTL1P2RX4RENCHRM2 | |
| SCHEMBL4221762 | 0.78 | P2RX4 (0.41) | ALOX5L3MBTL1P2RX4CHRM2CHRM1 | |
| SCHEMBL4669085 | 0.76 | ALOX5 (0.36) | ALOX5L3MBTL1P2RX4RENCHRM2 | |
| SCHEMBL11996613 | 0.72 | P2RX4 (0.41) | ALOX5L3MBTL1P2RX4 | |
| SCHEMBL15691733 | 0.71 | ALDH1A1 (0.44) | — | |
| SCHEMBL2596466 | 0.70 | P2RX4 (0.45) | ALOX5L3MBTL1P2RX4CHRM2CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1879882-A1 | 3 -M0N0- AND 3 , 5-DISUBSTITUTED PIPERIDINE DERIVATIVES AS RENIN INHIBITORS | Novartis AG (CH) | 2008-01-23 | — | — | EP | disclosed |
| WO-2006117183-A1 | 3 -M0N0- AND 3 , 5-DISUBSTITUTED PIPERIDINE DERIVATIVES AS RENIN INHIBITORS | NOVARTIS AG (CH) | 2006-11-09 | — | — | WO | disclosed |