Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.62 |
| ▸ | MEN1 | O00255 | 2/20 | 0.62 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.62 |
| ▸ | MGLL | Q99685 | 2/20 | 0.51 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | DRD4 | P21917 | 1/20 | 0.47 |
| ▸ | DRD3 | P35462 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL728685 | 0.86 | KMT2A (0.72) | KMT2AMEN1CYP2D6MGLLHSD11B1 | |
| Bicarbonate SCHEMBL11484457 | 0.82 | KMT2A (0.68) | KMT2AMEN1CYP2D6MGLLHSD11B1 | |
| SCHEMBL8119800 | 0.82 | KMT2A (0.68) | KMT2AMEN1CYP2D6MGLLHSD11B1 | |
| SCHEMBL4673866 | 0.81 | MGLL (0.51) | KMT2AMEN1CYP2D6MGLLHSD11B1 | |
| SCHEMBL4671500 | 0.81 | HSD11B1 (0.58) | MGLLHSD11B1POLBALDH1A1 | |
| SCHEMBL2297101 | 0.81 | MGLL (0.58) | KMT2AMEN1MGLLHSD11B1LMNA | |
| SCHEMBL654047 | 0.81 | HTR2A (0.49) | KMT2AMEN1MGLLHSD11B1ALDH1A1 | |
| SCHEMBL507614 | 0.81 | KMT2A (0.66) | KMT2AMEN1CYP2D6MGLLHSD11B1 | |
| SCHEMBL4675008 | 0.81 | NPC1 (0.71) | KMT2AMEN1MGLLHSD11B1POLB | |
| SCHEMBL4671079 | 0.81 | MEN1 (0.56) | KMT2AMEN1CYP2D6HTTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0958287-B2 | SULFAMIDE-METALLOPROTEASE INHIBITORS | HOFFMANN LA ROCHE (CH) | 2008-04-09 | — | — | EP | disclosed |
| EP-0958287-B1 | SULFAMIDE-METALLOPROTEASE INHIBITORS | HOFFMANN LA ROCHE (CH) | 2002-09-11 | — | — | EP | disclosed |
| US-6376506-B1 | REACTING SULFAMOYL OXAZOLIDONE WITH (1,2,3,4)-TETRAHYDRO-BETA-CARBOLINE TO FORM INHIBITOR; USED TO TREAT ARTHRITIS, OSTEOPOROSIS, PERIODONTAL DISEASE, CARDIOVASCULAR DISEASES, MULTIPLE SCLEROSIS, AND TUMORS | SYNTEX (U.S.A.) LLC | 2002-04-23 | — | — | US | disclosed |