Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.72 |
| ▸ | MEN1 | O00255 | 2/20 | 0.72 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.72 |
| ▸ | MGLL | Q99685 | 2/20 | 0.58 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.58 |
| ▸ | HTT | P42858 | 1/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | NPC1 | O15118 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.55 |
| ▸ | LMNA | P02545 | 3/20 | 0.55 |
| ▸ | DRD4 | P21917 | 1/20 | 0.53 |
| ▸ | DRD3 | P35462 | 1/20 | 0.53 |
| ▸ | CES2 | O00748 | 1/20 | 0.52 |
| ▸ | CES1 | P23141 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL11484457 | 0.96 | KMT2A (0.68) | KMT2AMEN1CYP2D6MGLLHSD11B1 | |
| SCHEMBL14596908 | 0.92 | KMT2A (0.64) | KMT2AMEN1CYP2D6MGLLHSD11B1 | |
| SCHEMBL8119800 | 0.91 | KMT2A (0.68) | KMT2AMEN1CYP2D6MGLLHSD11B1 | |
| SCHEMBL507614 | 0.90 | KMT2A (0.66) | KMT2AMEN1CYP2D6MGLLHSD11B1 | |
| SCHEMBL22542168 | 0.87 | KMT2A (0.58) | KMT2AMEN1CYP2D6MGLLHSD11B1 | |
| SCHEMBL18084742 | 0.87 | KMT2A (0.58) | KMT2AMEN1CYP2D6MGLLHSD11B1 | |
| SCHEMBL17914339 | 0.87 | KMT2A (0.58) | KMT2AMEN1CYP2D6MGLLHSD11B1 | |
| SCHEMBL4670951 | 0.86 | KMT2A (0.62) | KMT2AMEN1CYP2D6MGLLHSD11B1 | |
| SCHEMBL20134881 | 0.86 | POLB (0.62) | KMT2AMEN1CYP2D6MGLLHSD11B1 | |
| SCHEMBL1582773 | 0.86 | KMT2A (0.96) | KMT2AMEN1CYP2D6MGLLHSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 143 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030220496-A1 | Novel intermediates useful for the preparation of antihistaminic piperidine derivatives | MERRELL PHARMACEUTICALS, INC. | 2003-11-27 | — | — | US | claimed |
| US-6548675-B2 | 1-Cyclopropylcarbonyl-2-hydroxy(optional),4-isopropylbenzene used as starting materials for 1-((2-hydroxy(optional),4-alkylphenyl)carbonylalkyl-),4-(diphenylmethyl -)piperidine derivatives; antihistamines; antiallergens; bronchodilators | MERRELL PHARMACEUTICALS INC. | 2003-04-15 | — | — | US | claimed |
| US-20020198407-A1 | Novel intermediates useful for the preparation of antihistaminic piperidine derivatives | MERRELL PHARMACEUTICALS INC. | 2002-12-26 | — | — | US | claimed |
| EP-1260504-A1 | Process for the preparation of antihistaminic 4-diphenylmethyl piperidine derivatives | MERRELL PHARMACEUTICALS INC. (US) | 2002-11-27 | — | — | EP | claimed |
| US-20020077482-A1 | Novel intermediates useful for the preparation of antihistaminic piperidine derivatives | MERRELL DOW PHARMACEUTICALS INC. | 2002-06-20 | — | — | US | claimed |
| US-20020007085-A1 | Novel intermediates useful for the preparation of antihistaminic piperidine derivatives | MERRELL PHARMACEUTICALS INC. | 2002-01-17 | — | — | US | claimed |
| US-20010031895-A1 | Novel intermediates useful for the preparation of antihistaminic piperidine derivatives | MERRELL DOW PHARMACEUTICALS INC. | 2001-10-18 | — | — | US | claimed |
| US-20010021791-A1 | Novel intermediates useful for the preparation of antihistaminic piperidine derivatives | MERRELL PHARMACEUTICALS INC. | 2001-09-13 | — | — | US | claimed |
| US-20010020114-A1 | Novel intermediates useful for the preparation of antihistaminic piperidine derivatives | MERRELL PHARMACEUTICALS INC. | 2001-09-06 | — | — | US | claimed |
| US-20010018521-A1 | Novel intermediates useful for the preparation of antihistaminic piperidine derivatives | MERRELL PHARMACEUTICALS INC. | 2001-08-30 | — | — | US | claimed |
| US-20010000038-A1 | Novel intermediates useful for the preparation of antihistaminic piperidine derivatives | CHATTEM INC. | 2001-03-15 | — | — | US | claimed |
| JP-H08512028-A | — | — | 1996-12-17 | — | — | JP | claimed |
| EP-0705245-A1 | NOVEL INTERMEDIATES FOR THE PREPARATION OF ANTIHISTAMINIC 4-DIPHENYLMETHYL/DIPHENYLMETHOXY PIPERIDINE DERIVATIVES | MERRELL PHARMACEUTICALS INC. (US) | 1996-04-10 | — | — | EP | claimed |
| WO-1995000480-A1 | NOVEL INTERMEDIATES FOR THE PREPARATION OF ANTIHISTAMINIC 4-DIPHENYLMETHYL/DIPHENYLMETHOXY PIPERIDINE DERIVATIVES | MERRELL PHARMACEUTICALS INC. (US) | 1995-01-05 | — | — | WO | claimed |
| CN-119118807-A | Method for synthesizing aryl butanone by ligand-regulated nickel-catalyzed aryl cyclopropyl ketone ring-opening hydrogenation | 陕西师范大学 | 2024-12-13 | — | — | CN | disclosed |
| EP-3585775-B1 | AZETIDINE COMPOUNDS AS GPR119 MODULATORS FOR THE TREATMENT OF DIABETES, OBESITY, DYSLIPIDEMIA AND RELATED DISORDERS | SANOFI SA (FR) | 2022-04-06 | — | — | EP | disclosed |
| US-20200148668-A1 | DECARBOXYLATIVE CROSS-COUPLING AND APPLICATIONS THEREOF | THE TRUSTEES OF PRINCETON UNIVERSITY | 2020-05-14 | — | — | US | disclosed |
| WO-1995000480-A1 | NOVEL INTERMEDIATES FOR THE PREPARATION OF ANTIHISTAMINIC 4-DIPHENYLMETHYL/DIPHENYLMETHOXY PIPERIDINE DERIVATIVES | MERRELL PHARMACEUTICALS INC. (US) | 1995-01-05 | — | — | WO | disclosed |
| US-4160829-A | ANTIBIOTICS | GIST-BROCADES N.V. (NL) | 1979-07-10 | — | — | US | disclosed |
| US-4137324-A | Optionally substituted phenyl-α-cyclopropyl acetic acid esters and use as insecticides | NATIONAL RESEARCH DEVELOPMENT CORPORATION (GB) | 1979-01-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20010000038-A1 | Novel intermediates useful for the preparation of antihistaminic piperidine derivatives | HRH1, HRH3, HRH4 | KMT2A 1588/4885MEN1 2722/4885CYP2D6 553/4885 |
| US-20020198407-A1 | Novel intermediates useful for the preparation of antihistaminic piperidine derivatives | HRH1, HRH3, HRH4 | KMT2A 1895/4885MEN1 2020/4885CYP2D6 372/4885 |
| US-20010020114-A1 | Novel intermediates useful for the preparation of antihistaminic piperidine derivatives | HRH1, HRH3, HRH4 | KMT2A 2070/4885MEN1 2716/4885CYP2D6 494/4885 |
| US-20030220496-A1 | Novel intermediates useful for the preparation of antihistaminic piperidine derivatives | HRH1, HRH3, HRH4 | KMT2A 1588/4885MEN1 2722/4885CYP2D6 553/4885 |
| US-20010021791-A1 | Novel intermediates useful for the preparation of antihistaminic piperidine derivatives | HRH1, HRH3, HRH4 | KMT2A 2014/4885MEN1 2111/4885CYP2D6 388/4885 |
| US-20010031895-A1 | Novel intermediates useful for the preparation of antihistaminic piperidine derivatives | HRH1, HRH4, HRH3 | KMT2A 2187/4885MEN1 2358/4885CYP2D6 428/4885 |
| US-20020077482-A1 | Novel intermediates useful for the preparation of antihistaminic piperidine derivatives | HRH1, HRH3, HRH4 | KMT2A 1998/4885MEN1 2671/4885CYP2D6 468/4885 |
| US-20010018521-A1 | Novel intermediates useful for the preparation of antihistaminic piperidine derivatives | HRH1, HRH3, HRH4 | KMT2A 2055/4885MEN1 2708/4885CYP2D6 433/4885 |
| US-20020007085-A1 | Novel intermediates useful for the preparation of antihistaminic piperidine derivatives | HRH1, HRH3, HRH4 | KMT2A 2217/4885MEN1 2320/4885CYP2D6 416/4885 |
| US-20200148668-A1 | DECARBOXYLATIVE CROSS-COUPLING AND APPLICATIONS THEREOF | PPOX, DDO, DDC | KMT2A 1610/4885MEN1 2965/4885CYP2D6 647/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.