Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | KMO | O15229 | 2/20 | 0.40 |
| ▸ | CDK2 | P24941 | 2/20 | 0.39 |
| ▸ | GSK3B | P49841 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.36 |
| ▸ | CSF1R | P07333 | 1/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.36 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4669687 | 1.00 | MEN1 (0.43) | MEN1KMT2APOLBCTDSP1RAB9A | |
| SCHEMBL16841763 | 0.80 | MEN1 (0.52) | MEN1KMT2APOLBCTDSP1RAB9A | |
| SCHEMBL12326172 | 0.71 | PTGS2 (0.53) | MEN1KMT2APOLBKMONPC1 | |
| SCHEMBL577754 | 0.70 | KMO (0.43) | MEN1KMT2APOLBKMOMAPT | |
| SCHEMBL3997395 | 0.68 | DYRK1A (0.54) | MEN1KMT2APOLBKMOCDK2 | |
| SCHEMBL2751068 | 0.68 | S1PR1 (0.62) | ADORA2AADORA1 | |
| SCHEMBL2753487 | 0.68 | S1PR1 (0.55) | SMN1; SMN2NPC1MAPTADORA2AADORA1 | |
| SCHEMBL28264454 | 0.66 | CLK4 (0.52) | MEN1KMT2ARAB9AKMOSMN1; SMN2 | |
| SCHEMBL20449975 | 0.66 | DYRK1A (0.77) | MEN1KMT2APOLBKMODYRK1A | |
| SCHEMBL27675155 | 0.66 | ADORA2A (0.45) | RAB9AKMOPTGS2PTGS1ADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1611123-B1 | TIE-2 MODULATORS AND METHODS OF USE | EXELIXIS INC (US) | 2013-10-02 | — | — | EP | disclosed |
| EP-1611123-A4 | TIE-2 MODULATORS AND METHODS OF USE | EXELIXIS INC (US) | 2008-07-02 | — | — | EP | disclosed |
| EP-1611123-A2 | TIE-2 MODULATORS AND METHODS OF USE | Exelixis, Inc. (US) | 2006-01-04 | — | — | EP | disclosed |
| WO-2004091480-A2 | TIE-2 MODULATORS AND METHODS OF USE | EXELIXIS, INC. (US) | 2004-10-28 | — | — | WO | disclosed |