Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTB4R | Q15722 | 4/20 | 0.39 |
| ▸ | RPS6KB2 | Q9UBS0 | 2/20 | 0.39 |
| ▸ | DAO | P14920 | 3/20 | 0.35 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.34 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.34 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | RGS12 | O14924 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | APEX1 | P27695 | 1/20 | 0.33 |
| ▸ | THPO | P40225 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30571177 | 0.86 | RPS6KB2 (0.49) | LTB4RRPS6KB2DAOAKR1B1HSD17B10 | |
| SCHEMBL5818131 | 0.81 | DAO (0.47) | LTB4RRPS6KB2DAOAKR1B1HSD17B10 | |
| SCHEMBL4671588 | 0.81 | LTB4R (0.39) | LTB4RRPS6KB2DAOAKR1B1HSD17B10 | |
| SCHEMBL1246005 | 0.79 | LTB4R (0.44) | LTB4RRPS6KB2DAOAKR1B1HSD17B10 | |
| SCHEMBL10717559 | 0.77 | LTB4R (0.56) | LTB4RRPS6KB2DAOAKR1B1MAPT | |
| SCHEMBL28650107 | 0.75 | LTB4R (0.35) | LTB4RRPS6KB2DAOHSD17B10GABRA5 | |
| SCHEMBL1492936 | 0.74 | CES2 (0.45) | DAOAKR1B1HSD17B10GABRA5GABRB2 | |
| SCHEMBL16564282 | 0.73 | DAO (0.56) | LTB4RRPS6KB2DAOAKR1B1HSD17B10 | |
| SCHEMBL27630654 | 0.72 | KEAP1 (0.45) | LTB4RDAOAKR1B1HSD17B10GABRA5 | |
| SCHEMBL27809521 | 0.72 | KDM4E (0.41) | DAOAKR1B1HSD17B10GABRA5GABRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100491323-C | Biaryloxymethylarenecarboxylic acids compound | HOFFMANN LA ROCHE (CH) | 2009-05-27 | — | — | CN | disclosed |
| EP-1663936-B1 | BIARYLOXYMETHYLARENE-CARBOXYLIC ACIDS | HOFFMANN LA ROCHE (CH) | 2008-01-09 | — | — | EP | disclosed |
| CN-1812956-A | Biaryloxymethylarenecarboxylic acids as glycogen synthase activator | HOFFMANN LA ROCHE (CH) | 2006-08-02 | — | — | CN | disclosed |