Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP26A1 | O43174 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.35 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.34 |
| ▸ | KDM1A | O60341 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | TYR | P14679 | 1/20 | 0.33 |
| ▸ | CA7 | P43166 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4672835 | 1.00 | CYP26A1 (0.39) | CYP26A1ALDH1A1MAPTSMN1; SMN2KDM4E | |
| SCHEMBL4619546 | 0.89 | CYP1A2 (0.44) | CYP26A1ALDH1A1MAPTSMN1; SMN2KDM4E | |
| SCHEMBL4619550 | 0.89 | CYP1A2 (0.44) | CYP26A1ALDH1A1MAPTSMN1; SMN2KDM4E | |
| SCHEMBL1594293 | 0.82 | CYP26A1 (0.41) | CYP26A1ALDH1A1MAPTSMN1; SMN2KDM4E | |
| SCHEMBL1594296 | 0.82 | CYP26A1 (0.41) | CYP26A1ALDH1A1MAPTSMN1; SMN2KDM4E | |
| SCHEMBL1594587 | 0.81 | MMP1 (0.47) | ALDH1A1MAPTSMN1; SMN2KDM4ECYP2C19 | |
| SCHEMBL1593920 | 0.75 | TRPV1 (0.56) | ALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL959172 | 0.74 | MAPT (0.43) | CYP26A1ALDH1A1MAPTSMN1; SMN2KDM4E | |
| SCHEMBL959171 | 0.74 | MAPT (0.43) | CYP26A1ALDH1A1MAPTSMN1; SMN2KDM4E | |
| SCHEMBL3407627 | 0.73 | MAPT (0.65) | CYP26A1ALDH1A1MAPTSMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7919624-B2 | VR1 vanilloid receptor antagonists with a iononic substructure | PHARMESTE S.R.L. (IT) | 2011-04-05 | — | — | US | disclosed |
| US-20100035923-A1 | VR1 VANILLOID RECEPTOR ANTAGONISTS WITH A IONONIC SUBSTRUCTURE | PHARMESTE S.R.L. (IT) | 2010-02-11 | — | — | US | disclosed |
| EP-1889837-A1 | VR1 vanilloid receptor antagonists with a iononic substructure | Pharmeste S.r.l. (IT) | 2008-02-20 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100035923-A1 | VR1 VANILLOID RECEPTOR ANTAGONISTS WITH A IONONIC SUBSTRUCTURE | TRPV1, TRPV6, TRPV2 | CYP26A1 705/4885ALDH1A1 1139/4885MAPT 4168/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.