Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | OGA | O60502 | 4/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.40 |
| ▸ | ABL1 | P00519 | 3/20 | 0.39 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.39 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.39 |
| ▸ | LPAR2 | Q9HBW0 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1000263 | 0.79 | LPAR1 (0.51) | LMNAMAPTKMT2AMEN1POLB | |
| SCHEMBL4959755 | 0.75 | LMNA (0.48) | LMNAMAPTKMT2AMEN1POLB | |
| SCHEMBL4965155 | 0.73 | OGA (0.43) | LMNAMAPTKMT2AMEN1OGA | |
| SCHEMBL1235081 | 0.73 | PIK3CG (0.48) | POLBPIK3C3 | |
| SCHEMBL4960521 | 0.70 | LMNA (0.45) | LMNAMAPTKMT2AMEN1OGA | |
| SCHEMBL1058013 | 0.69 | L3MBTL1 (0.52) | MAPTKMT2AMEN1POLBGAA | |
| SCHEMBL16903932 | 0.68 | POLB (0.53) | LMNAMAPTKMT2AMEN1POLB | |
| SCHEMBL1939095 | 0.66 | L3MBTL1 (0.51) | LMNAMAPTKMT2AMEN1POLB | |
| SCHEMBL1237592 | 0.66 | OGA (0.45) | LMNAMAPTKMT2AOGASMN1; SMN2 | |
| SCHEMBL1940087 | 0.66 | HTT (0.46) | LMNAMAPTKMT2AMEN1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080221180-A1 | Thiazole Derivatives and Use Thereof | LABORATORIES SERONO SA (CH) | 2008-09-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080221180-A1 | Thiazole Derivatives and Use Thereof | PDGFRB, PDGFRA, TEC | LMNA 4765/4885MAPT 1418/4885KMT2A 4737/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.