Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 8/20 | 0.53 |
| ▸ | HTR1A | P08908 | 6/20 | 0.47 |
| ▸ | DRD1 | P21728 | 1/20 | 0.47 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.47 |
| ▸ | HTR1B | P28222 | 1/20 | 0.47 |
| ▸ | HTR2A | P28223 | 1/20 | 0.47 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.47 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.44 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.44 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.44 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8109654 | 0.86 | SLC6A4 (0.68) | SLC6A4HTR1ADRD1SLC6A2HTR1B | |
| SCHEMBL4671288 | 0.82 | SLC6A4 (0.50) | SLC6A4HTR1ADRD1SLC6A2HTR1B | |
| SCHEMBL4671600 | 0.82 | SLC6A4 (0.49) | SLC6A4HTR1ADRD1SLC6A2HTR1B | |
| SCHEMBL4673535 | 0.81 | OPRM1 (0.56) | SLC6A4HTR1ADRD1SLC6A2HTR1B | |
| SCHEMBL7316005 | 0.81 | SLC6A4 (0.48) | SLC6A4HTR1ADRD1SLC6A2HTR1B | |
| SCHEMBL4673257 | 0.80 | HSD11B1 (0.54) | SLC6A4HTR1ADRD1SLC6A2HTR1B | |
| SCHEMBL4672939 | 0.75 | OPRM1 (0.50) | SLC6A4HTR1ADRD1HTR2AOPRM1 | |
| SCHEMBL4677237 | 0.74 | SLC6A4 (0.50) | SLC6A4HTR1ADRD1SLC6A2HTR1B | |
| SCHEMBL8096606 | 0.74 | SLC6A4 (0.50) | SLC6A4HTR1ADRD1SLC6A2HTR1B | |
| SCHEMBL8149530 | 0.74 | SLC6A4 (0.51) | SLC6A4HTR1AHTR1BOPRM1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0958287-B2 | SULFAMIDE-METALLOPROTEASE INHIBITORS | HOFFMANN LA ROCHE (CH) | 2008-04-09 | — | — | EP | disclosed |
| EP-0958287-B1 | SULFAMIDE-METALLOPROTEASE INHIBITORS | HOFFMANN LA ROCHE (CH) | 2002-09-11 | — | — | EP | disclosed |
| US-6376506-B1 | REACTING SULFAMOYL OXAZOLIDONE WITH (1,2,3,4)-TETRAHYDRO-BETA-CARBOLINE TO FORM INHIBITOR; USED TO TREAT ARTHRITIS, OSTEOPOROSIS, PERIODONTAL DISEASE, CARDIOVASCULAR DISEASES, MULTIPLE SCLEROSIS, AND TUMORS | SYNTEX (U.S.A.) LLC | 2002-04-23 | — | — | US | disclosed |