Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 3/20 | 0.56 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.56 |
| ▸ | OPRL1 | P41146 | 3/20 | 0.56 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.53 |
| ▸ | SLC6A4 | P31645 | 7/20 | 0.53 |
| ▸ | HTR1A | P08908 | 8/20 | 0.51 |
| ▸ | HTR7 | P34969 | 3/20 | 0.49 |
| ▸ | DRD2 | P14416 | 2/20 | 0.49 |
| ▸ | HTR6 | P50406 | 2/20 | 0.49 |
| ▸ | HTR2A | P28223 | 2/20 | 0.49 |
| ▸ | DRD1 | P21728 | 1/20 | 0.48 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.48 |
| ▸ | HTR1B | P28222 | 1/20 | 0.48 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8109656 | 0.84 | OPRM1 (0.68) | OPRM1OPRK1OPRL1HSD11B1SLC6A4 | |
| SCHEMBL4673530 | 0.81 | SLC6A4 (0.53) | OPRM1OPRK1OPRL1HSD11B1SLC6A4 | |
| SCHEMBL8103994 | 0.81 | OPRM1 (0.64) | OPRM1OPRK1OPRL1HSD11B1SLC6A4 | |
| SCHEMBL4671289 | 0.79 | SLC6A4 (0.52) | OPRM1OPRK1OPRL1HSD11B1SLC6A4 | |
| SCHEMBL4671603 | 0.79 | HSD11B1 (0.56) | OPRM1OPRK1OPRL1HSD11B1SLC6A4 | |
| SCHEMBL4673580 | 0.78 | HTR1B (0.71) | OPRM1OPRK1OPRL1SLC6A4HTR1A | |
| SCHEMBL7478833 | 0.77 | SLC6A4 (0.57) | OPRM1OPRK1OPRL1HSD11B1SLC6A4 | |
| SCHEMBL7316014 | 0.77 | HSD11B1 (0.54) | OPRM1OPRK1OPRL1HSD11B1SLC6A4 | |
| SCHEMBL7486361 | 0.77 | SLC6A4 (0.57) | OPRM1OPRK1OPRL1HSD11B1SLC6A4 | |
| SCHEMBL5340537 | 0.77 | HSD11B1 (0.68) | OPRM1OPRK1OPRL1HSD11B1SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0958287-B2 | SULFAMIDE-METALLOPROTEASE INHIBITORS | HOFFMANN LA ROCHE (CH) | 2008-04-09 | — | — | EP | disclosed |
| EP-0958287-B1 | SULFAMIDE-METALLOPROTEASE INHIBITORS | HOFFMANN LA ROCHE (CH) | 2002-09-11 | — | — | EP | disclosed |
| US-6376506-B1 | REACTING SULFAMOYL OXAZOLIDONE WITH (1,2,3,4)-TETRAHYDRO-BETA-CARBOLINE TO FORM INHIBITOR; USED TO TREAT ARTHRITIS, OSTEOPOROSIS, PERIODONTAL DISEASE, CARDIOVASCULAR DISEASES, MULTIPLE SCLEROSIS, AND TUMORS | SYNTEX (U.S.A.) LLC | 2002-04-23 | — | — | US | disclosed |