Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRL1 | P41146 | 10/20 | 0.58 |
| ▸ | OPRM1 | P35372 | 6/20 | 0.58 |
| ▸ | OPRK1 | P41145 | 6/20 | 0.58 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.47 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.42 |
| ▸ | TACR1 | P25103 | 2/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4352504 | 0.79 | OPRL1 (0.68) | OPRL1OPRM1OPRK1 | |
| SCHEMBL25547484 | 0.79 | OPRL1 (0.53) | OPRL1OPRM1OPRK1OPRD1POLB | |
| SCHEMBL11476687 | 0.79 | OPRL1 (0.53) | OPRL1OPRM1OPRK1OPRD1POLB | |
| SCHEMBL317531 | 0.78 | OPRL1 (0.47) | OPRL1OPRM1OPRK1 | |
| SCHEMBL11251238 | 0.77 | OPRL1 (0.42) | OPRL1OPRM1OPRK1OPRD1TACR1 | |
| SCHEMBL11815569 | 0.76 | OPRL1 (0.50) | OPRL1OPRM1OPRK1OPRD1SLC6A4 | |
| SCHEMBL7815717 | 0.75 | OPRL1 (0.68) | OPRL1OPRM1OPRK1OPRD1SIGMAR1 | |
| SCHEMBL10060840 | 0.75 | OPRL1 (0.68) | OPRL1OPRM1OPRK1OPRD1SIGMAR1 | |
| SCHEMBL6659414 | 0.75 | OPRL1 (0.56) | OPRL1OPRM1OPRK1OPRD1ALDH1A1 | |
| SCHEMBL6659407 | 0.75 | OPRL1 (0.56) | OPRL1OPRM1OPRK1OPRD1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5239110-A | Phenylcyclohexanol derivatives as agents for treating CNS disorders | STERLING WINTHROP, INC. (US) | 1993-08-24 | — | — | US | claimed |
| EP-2600863-B1 | USE OF SIGMA LIGANDS IN OPIOID-INDUCED HYPERALGESIA | ESTEVE LABOR DR (ES) | 2018-03-28 | — | — | EP | disclosed |
| EP-2646025-B1 | USE OF SIGMA LIGANDS IN BONE CANCER PAIN | ESTEVE LABOR DR (ES) | 2017-03-15 | — | — | EP | disclosed |
| EP-2571501-B1 | SIGMA LIGANDS FOR THE PREVENTION AND/OR TREATMENT OF EMESIS INDUCED BY CHEMOTHERAPY OR RADIOTHERAPY | ESTEVE LABOR DR (ES) | 2016-03-02 | — | — | EP | disclosed |
| EP-2460519-A1 | Use of sigma ligands in bone cancer pain | Laboratorios Del. Dr. Esteve, S.A. (ES) | 2012-06-06 | — | — | EP | disclosed |
| EP-2415471-A1 | Use of sigma ligands in opioid-induced hyperalgesia | Laboratorios Del. Dr. Esteve, S.A. (ES) | 2012-02-08 | — | — | EP | disclosed |
| EP-2388005-A1 | Sigma ligands for the prevention and/or treatment of emesis induced by chemotherapy or radiotherapy | Laboratorios Del. Dr. Esteve, S.A. (ES) | 2011-11-23 | — | — | EP | disclosed |
| EP-2353598-A1 | Sigma ligands for use in the prevention and/or treatment of postoperative pain | Laboratorios Del. Dr. Esteve, S.A. (ES) | 2011-08-10 | — | — | EP | disclosed |
| US-5239110-A | Phenylcyclohexanol derivatives as agents for treating CNS disorders | STERLING WINTHROP, INC. (US) | 1993-08-24 | — | — | US | disclosed |