Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 7/20 | 0.41 |
| ▸ | SIRT3 | Q9NTG7 | 4/20 | 0.38 |
| ▸ | PPARG | P37231 | 4/20 | 0.37 |
| ▸ | PPARA | Q07869 | 4/20 | 0.37 |
| ▸ | PPARD | Q03181 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | THRA | P10827 | 2/20 | 0.36 |
| ▸ | THRB | P10828 | 2/20 | 0.36 |
| ▸ | KDM5A | P29375 | 2/20 | 0.36 |
| ▸ | KDM7A | Q6ZMT4 | 2/20 | 0.36 |
| ▸ | MLNR | O43193 | 1/20 | 0.36 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.36 |
| ▸ | PHF2 | O75151 | 1/20 | 0.36 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.36 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4674314 | 0.89 | NR1H4 (0.48) | NR1H4PTPN1SIRT3PPARGPPARA | |
| SCHEMBL4728486 | 0.86 | NR1H4 (0.42) | NR1H4PTPN1SIRT3THRATHRB | |
| SCHEMBL4672473 | 0.82 | PTPN1 (0.51) | NR1H4PTPN1SIRT3 | |
| SCHEMBL4674317 | 0.80 | NR1H4 (0.49) | NR1H4PTPN1SIRT3ALDH1A1TP53 | |
| SCHEMBL4672520 | 0.78 | PTPN1 (0.50) | NR1H4PTPN1SIRT3ALDH1A1TP53 | |
| SCHEMBL4674079 | 0.77 | PTPN1 (0.52) | NR1H4PTPN1SIRT3SMN1; SMN2THRA | |
| SCHEMBL4673738 | 0.75 | PTPN1 (0.52) | NR1H4PTPN1SIRT3ABCB1 | |
| SCHEMBL4674024 | 0.74 | PTPN1 (0.43) | NR1H4PTPN1SMN1; SMN2MEN1MAPT | |
| SCHEMBL4670614 | 0.74 | PTPN1 (0.39) | NR1H4PTPN1SIRT3KDM7AMAPT | |
| SCHEMBL4670309 | 0.74 | PTPN1 (0.43) | NR1H4PTPN1SIRT3THRATHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1397341-B1 | 6-(ARYL-AMIDO OR ARYL-AMIDOMETHYL)-NAPHTHALEN-2-YLOXY-ACIDIC DERIVATIVES AS INHIBITORS OF PLASMINOGEN ACTIVATOR INHIBITOR TYPE-1 (PAI-1) | WYETH CORP (US) | 2008-08-06 | — | — | EP | claimed |