Sugi Predict

Sugi Predict / Compounds / SCHEMBL4673743

SCHEMBL4673743

SCHEMBL4673743

O=C(Cc1ccc(Cl)cc1)Oc1ccc(Cl)cc1

nearest known ligand 0.71

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
▸ KMT2A Q03164 3/20 0.71
▸ CA2 P00918 3/20 0.55
▸ CA5A P35218 2/20 0.55
▸ POLB P06746 2/20 0.51
▸ CYP19A1 P11511 1/20 0.51
▸ L3MBTL1 Q9Y468 2/20 0.50
▸ LMNA P02545 1/20 0.50
▸ GAA P10253 1/20 0.50
▸ SMN1; SMN2 Q16637 1/20 0.50
▸ KLK7 P49862 2/20 0.49
▸ ASAH1 Q13510 1/20 0.48
▸ MAPT P10636 1/20 0.47
▸ TSHR P16473 1/20 0.47
▸ CNR2 P34972 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6937444 0.91 KMT2A (0.68) KMT2ACA2CA5AL3MBTL1LMNA
SCHEMBL7807836 0.91 KMT2A (0.62) KMT2ACA2CA5APOLBCYP19A1
SCHEMBL11783599 0.91 KMT2A (0.61) KMT2ACYP19A1L3MBTL1SMN1; SMN2ASAH1
SCHEMBL7566982 0.83 KMT2A (0.53) KMT2APOLBLMNAMAPT
SCHEMBL9108360 0.83 KMT2A (0.54) KMT2ACA2CA5AGAA
SCHEMBL414384 0.82 SENP1 (0.59) KMT2ACA2CYP19A1L3MBTL1ASAH1
SCHEMBL8855417 0.81 POLB (0.56) KMT2APOLBL3MBTL1LMNAKLK7
SCHEMBL643983 0.81 KMT2A (0.63) KMT2ALMNAMAPTTSHR
SCHEMBL1244295 0.81 KMT2A (0.54) KMT2AL3MBTL1LMNASMN1; SMN2MAPT
SCHEMBL4671096 0.81 KMT2A (0.55) KMT2AL3MBTL1LMNAMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114950533-B Prussian blue nanoflower preparation method and application thereof, and nanoflower structure adjusting method 湖南农业大学 2023-10-20 — — CN disclosed
CN-114950533-A Preparation method and application of prussian blue nanoflower and nanoflower structure adjusting method 湖南农业大学 2022-08-30 — — CN disclosed
CN-111172167-B Organic chlorine pesticide DDT aptamer and application thereof 华侨大学 2022-07-29 — — CN disclosed
CN-111172167-A Organic chlorine pesticide DDT aptamer and application thereof 华侨大学 2020-05-19 — — CN disclosed
EP-1318983-B1 SUBSTITUTED IMIDAZOLES AS HISTAMINE H1 AND H3 AGONISTS OR ANTAGONISTS SCHERING CORP (US) 2008-10-22 — — EP disclosed
EP-1590326-A4 SUBSTITUTED ALKYL AMIDO PIPERIDINES LUNDBECK & CO AS H (DK) 2008-04-30 — — EP disclosed
US-7199135-B2 Substituted alkyl amido piperidines H. LUNDBECK A/S (DK) 2007-04-03 — — US disclosed
US-20060217418-A1 Substituted alkyl amido piperidines H. LUNDBECK A/S (DK) 2006-09-28 — — US disclosed
US-20060084649-A9 Substituted alkyl amido piperidines SYNAPTIC PHARMACEUTICAL CORPORATION (US) 2006-04-20 — — US disclosed
EP-1590326-A2 SUBSTITUTED ALKYL AMIDO PIPERIDINES H. Lundbeck A/S (DK) 2005-11-02 — — EP disclosed
US-20020103235-A1 Substituted imidazoles as dual histamine H1 and H3 agonists or antagonists SCHERING CORPORATION 2002-08-01 — — US disclosed
WO-2002024658-A2 SUBSTITUTED IMIDAZOLES AS DUAL HISTAMINE H1 AND H3 AGONISTS OR ANTAGONISTS SCHERING CORPORATION (US) 2002-03-28 — — WO disclosed
WO-1994026702-A1 N-ACYL SULFAMIC ACID ESTERS (OR THIOESTERS), N-ACYL SULFONAMIDES, AND N-SULFONYL CARBAMIC ACID ESTERS (OR THIOESTERS) AS HYPERCHOLESTEROLEMIC AGENTS WARNER-LAMBERT COMPANY (US) 1994-11-24 — — WO disclosed
EP-0245637-B1 4,5,6,7-Tetrahydro-1H-imidazo[4,5-c]pyridine derivatives and analogs having antihypertensive activity WARNER-LAMBERT COMPANY (US) 1991-10-16 — — EP disclosed
US-4816463-A HYPERTENSION WARNER-LAMBERT COMPANY (US) 1989-03-28 — — US disclosed
US-4812462-A 4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid analogs having antihypertensive activity WARNER-LAMBERT COMPANY (US) 1989-03-14 — — US disclosed
EP-0245637-A1 4,5,6,7-Tetrahydro-1H-imidazo[4,5-c]pyridine derivatives and analogs having antihypertensive activity WARNER-LAMBERT COMPANY (US) 1987-11-19 — — EP disclosed
EP-0028305-B1 DIARYL COMPOUNDS AND PHARMACEUTICAL FORMULATIONS CONTAINING THEM THE WELLCOME FOUNDATION LIMITED (GB) 1984-02-01 — — EP disclosed
EP-0028305-A1 Diaryl compounds and pharmaceutical formulations containing them THE WELLCOME FOUNDATION LIMITED (GB) 1981-05-13 — — EP disclosed
US-4105762-A Metal salt complexes of 1-substituted aralkyl imidazoles, and methods and compositions for controlling phytopathogenic fungi using them ROHM AND HAAS COMPANY (US) 1978-08-08 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060084649-A9 Substituted alkyl amido piperidines MCHR1, MCHR2, MC1R KMT2A 1399/4885CA2 3206/4885CA5A 1477/4885
US-20020103235-A1 Substituted imidazoles as dual histamine H1 and H3 agonists or antagonists HRH3, HRH4, HRH2 KMT2A 140/4885CA2 838/4885CA5A 3881/4885
US-20060217418-A1 Substituted alkyl amido piperidines MCHR1, MCHR2, MC1R KMT2A 1399/4885CA2 3206/4885CA5A 1477/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.