Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM2B | Q8NHM5 | 13/20 | 0.53 |
| ▸ | HTR2A | P28223 | 4/20 | 0.50 |
| ▸ | HTR2C | P28335 | 4/20 | 0.50 |
| ▸ | DRD2 | P14416 | 3/20 | 0.50 |
| ▸ | HTR2B | P41595 | 2/20 | 0.50 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.50 |
| ▸ | HTR7 | P34969 | 1/20 | 0.46 |
| ▸ | HTR6 | P50406 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL467403 | 1.00 | KDM2B (0.53) | KDM2BHTR2AHTR2CDRD2HTR2B | |
| SCHEMBL467405 | 1.00 | KDM2B (0.53) | KDM2BHTR2AHTR2CDRD2HTR2B | |
| SCHEMBL8646880 | 1.00 | KDM2B (0.53) | KDM2BHTR2AHTR2CDRD2HTR2B | |
| SCHEMBL8642581 | 0.82 | SLC18A3 (0.62) | HTR2AHTR2CDRD2HTR2BSIGMAR1 | |
| SCHEMBL7444174 | 0.81 | HTR2A (0.59) | HTR2AHTR2CHTR7HTR6 | |
| SCHEMBL7444169 | 0.81 | HTR2A (0.59) | HTR2AHTR2CHTR7HTR6 | |
| SCHEMBL7444179 | 0.81 | HTR2A (0.59) | HTR2AHTR2CHTR7HTR6 | |
| SCHEMBL8642030 | 0.75 | HTR2A (0.45) | HTR2AHTR2CDRD2HTR7HTR6 | |
| SCHEMBL5410741 | 0.74 | DRD4 (0.58) | HTR2AHTR2CDRD2 | |
| SCHEMBL14502920 | 0.74 | DRD4 (0.58) | HTR2AHTR2CDRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2600863-B1 | USE OF SIGMA LIGANDS IN OPIOID-INDUCED HYPERALGESIA | ESTEVE LABOR DR (ES) | 2018-03-28 | — | — | EP | disclosed |
| EP-2646025-B1 | USE OF SIGMA LIGANDS IN BONE CANCER PAIN | ESTEVE LABOR DR (ES) | 2017-03-15 | — | — | EP | disclosed |
| EP-2531191-B1 | Sigma ligands for use in the prevention and/or treatment of postoperative pain | ESTEVE LABOR DR (ES) | 2016-03-30 | — | — | EP | disclosed |
| EP-2571501-B1 | SIGMA LIGANDS FOR THE PREVENTION AND/OR TREATMENT OF EMESIS INDUCED BY CHEMOTHERAPY OR RADIOTHERAPY | ESTEVE LABOR DR (ES) | 2016-03-02 | — | — | EP | disclosed |
| EP-2415471-A1 | Use of sigma ligands in opioid-induced hyperalgesia | Laboratorios Del. Dr. Esteve, S.A. (ES) | 2012-02-08 | — | — | EP | disclosed |
| EP-2388005-A1 | Sigma ligands for the prevention and/or treatment of emesis induced by chemotherapy or radiotherapy | Laboratorios Del. Dr. Esteve, S.A. (ES) | 2011-11-23 | — | — | EP | disclosed |