Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.61 |
| ▸ | TGFBR1 | P36897 | 3/20 | 0.50 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | CASP3 | P42574 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.45 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.45 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.43 |
| ▸ | HPGD | P15428 | 5/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.43 |
| ▸ | CASP1 | P29466 | 2/20 | 0.43 |
| ▸ | CASP7 | P55210 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5934317 | 0.84 | TRPV1 (0.67) | TRPV1TGFBR1ALDH1A1RAB9AKDM4E | |
| SCHEMBL18187537 | 0.76 | ALPL (0.51) | TRPV1TGFBR1ALDH1A1L3MBTL1NPC1 | |
| SCHEMBL4351466 | 0.75 | TRPV1 (0.53) | TRPV1 | |
| SCHEMBL18137682 | 0.74 | BRD4 (0.56) | ALDH1A1NPC1KDM4EHPGDSMN1; SMN2 | |
| SCHEMBL4728732 | 0.74 | RAB9A (0.55) | MDM2ALDH1A1L3MBTL1NPC1CASP3 | |
| SCHEMBL14444495 | 0.73 | NCOA1 (0.53) | TRPV1ALDH1A1L3MBTL1KDM4EHPGD | |
| SCHEMBL14430634 | 0.73 | TRPV1 (0.56) | TRPV1 | |
| SCHEMBL1498542 | 0.73 | KDM4E (0.50) | MDM2ALDH1A1L3MBTL1NPC1CASP3 | |
| SCHEMBL31697314 | 0.73 | KDM4E (0.50) | MDM2ALDH1A1L3MBTL1NPC1CASP3 | |
| SCHEMBL5472678 | 0.73 | TRPV1 (0.43) | TRPV1TGFBR1ALDH1A1L3MBTL1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1625119-B1 | SUBSTITUTED-1-PHTHALAZINAMINES AS VR-1 ANTAGONISTS | MERCK SHARP & DOHME (GB) | 2008-07-23 | — | — | EP | disclosed |
| US-7329659-B2 | Substituted-1-phthalazinamines as vr-1 antagonists | MERCK SHARP & DOHME LIMITED (GB) | 2008-02-12 | — | — | US | disclosed |
| US-20060229307-A1 | Substituted-1-phthalazinamines as vr-1 antagonists | MERCK SHARP & DOHME LTD. (GB) | 2006-10-12 | — | — | US | disclosed |
| EP-1625119-A1 | SUBSTITUTED-1-PHTHALAZINAMINES AS VR-1 ANTAGONISTS | MERCK SHARP & DOHME LTD. (GB) | 2006-02-15 | — | — | EP | disclosed |
| WO-2004099177-A1 | SUBSTITUTED-1-PHTHALAZINAMINES AS VR-1 ANTAGONISTS | MERCK SHARP & DOHME LIMITED (GB) | 2004-11-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060229307-A1 | Substituted-1-phthalazinamines as vr-1 antagonists | TRPV1, ARRB1, AVPR1A | TRPV1 1/4885TGFBR1 745/4885MDM2 2680/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.