Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | PIM1 | P11309 | 1/20 | 0.46 |
| ▸ | HTR6 | P50406 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.43 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.42 |
| ▸ | CYP2A13 | Q16696 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4677973 | 0.85 | ALDH1A1 (0.46) | ALDH1A1TSHRPIM1HTR6TP53 | |
| SCHEMBL4675239 | 0.83 | L3MBTL1 (0.46) | ALDH1A1TSHRPIM1TP53CHRM1 | |
| SCHEMBL4676101 | 0.81 | HTR6 (0.65) | ALDH1A1TSHRHTR6GSK3BL3MBTL1 | |
| SCHEMBL4676125 | 0.81 | HTR6 (0.72) | ALDH1A1TSHRPIM1HTR6TP53 | |
| SCHEMBL4676109 | 0.81 | HTR6 (0.52) | ALDH1A1TSHRHTR6TP53LMNA | |
| Hydrochloric Acid SCHEMBL4675355 | 0.80 | HTR6 (0.71) | ALDH1A1TSHRPIM1HTR6TP53 | |
| SCHEMBL2599677 | 0.77 | HTR6 (0.64) | ALDH1A1TSHRHTR6GSK3BL3MBTL1 | |
| SCHEMBL4678786 | 0.76 | HTR6 (0.53) | TSHRHTR6TP53LMNAL3MBTL1 | |
| SCHEMBL16131542 | 0.74 | L3MBTL1 (0.48) | ALDH1A1TSHRLMNAL3MBTL1KMT2A | |
| SCHEMBL16131515 | 0.73 | L3MBTL1 (0.70) | ALDH1A1HTR6TP53THRBGSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1562918-B1 | SUBSTITUTED BENZOXAZINONES AND USES THEREOF | HOFFMANN LA ROCHE (CH) | 2008-01-16 | — | — | EP | disclosed |
| US-7141562-B2 | Substituted benzoxazinones and uses thereof | ROCHE PALO ALTO LLC (US) | 2006-11-28 | — | — | US | disclosed |
| EP-1562918-A1 | SUBSTITUTED BENZOXAZINONES AND USES THEREOF | F. HOFFMANN-LA ROCHE AG (CH) | 2005-08-17 | — | — | EP | disclosed |
| WO-2004041792-A1 | SUBSTITUTED BENZOXAZINONES AND USES THEREOF | F. HOFFMANN-LA ROCHE AG (CH) | 2004-05-21 | — | — | WO | disclosed |
| US-20040092512-A1 | Substituted benzoxazinones and uses thereof | ROCHE PALO ALTO LLC | 2004-05-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040092512-A1 | Substituted benzoxazinones and uses thereof | CYP4X1, CYP3A5, CYP2D6 | ALDH1A1 389/4885TSHR 2485/4885PIM1 2714/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.