Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | RXRA | P19793 | 3/20 | 0.32 |
| ▸ | RXRB | P28702 | 1/20 | 0.32 |
| ▸ | RXRG | P48443 | 1/20 | 0.32 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.32 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.32 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.32 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.32 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.32 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4674950 | 0.80 | POLB (0.34) | ALDH1A1SMN1; SMN2RXRARXRBRXRG | |
| SCHEMBL3468200 | 0.78 | ESR1 (0.34) | HPGDL3MBTL1KDM4EALDH1A1ALDH2 | |
| SCHEMBL3080491 | 0.75 | ALDH1A1 (0.33) | ALDH1A1SMN1; SMN2RXRARXRBRXRG | |
| SCHEMBL3467850 | 0.74 | ESR1 (0.40) | HPGDL3MBTL1KDM4EALDH1A1ALDH2 | |
| SCHEMBL3068903 | 0.73 | PLA2G7 (0.38) | HPGDL3MBTL1KDM4EALDH1A1ALDH2 | |
| SCHEMBL3076991 | 0.68 | ALOX15 (0.49) | ALDH1A1SMN1; SMN2KMT2AMEN1FFAR1 | |
| SCHEMBL3081636 | 0.66 | GAA (0.52) | L3MBTL1ALDH1A1GAAMAPT | |
| SCHEMBL3082901 | 0.66 | CYP19A1 (0.49) | HPGDL3MBTL1KDM4EALDH1A1GAA | |
| SCHEMBL3073731 | 0.65 | GAA (0.43) | GAA | |
| SCHEMBL29007033 | 0.64 | HPGD (0.46) | HPGDL3MBTL1KDM4EALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1891026-A2 | CYCLOALKYLIDENE COMPOUNDS AS SELECTIVE ESTROGEN RECEPTOR MODULATORS | Smithkline Beecham Corporation (US) | 2008-02-27 | — | — | EP | disclosed |
| WO-2006127871-A2 | CYCLOALKYLIDENE COMPOUNDS AS SELECTIVE ESTROGEN RECEPTOR MODULATORS | SMITHKLINE BEECHAM CORPORATION (US) | 2006-11-30 | — | — | WO | disclosed |