Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.54 |
| ▸ | RAB9A | P51151 | 3/20 | 0.54 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 5/20 | 0.46 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.46 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.45 |
| ▸ | PPARA | Q07869 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | PPARG | P37231 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | SMPD1 | P17405 | 3/20 | 0.42 |
| ▸ | PPARD | Q03181 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.41 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.41 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.41 |
| ▸ | PDE5A | O76074 | 1/20 | 0.41 |
| ▸ | PDE1A | P54750 | 1/20 | 0.41 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4671564 | 0.90 | NPC1 (0.50) | NPC1RAB9AMAPTTP53SMN1; SMN2 | |
| SCHEMBL3561666 | 0.82 | NPC1 (0.57) | NPC1RAB9AMRGPRX4MAPTPTGDR2 | |
| SCHEMBL4675305 | 0.78 | MAPT (0.58) | NPC1RAB9AMRGPRX4MAPTPTGDR2 | |
| SCHEMBL3556746 | 0.72 | MAPT (0.72) | NPC1RAB9AMRGPRX4MAPTPTGDR2 | |
| SCHEMBL5011901 | 0.72 | NPC1 (0.64) | NPC1RAB9AMRGPRX4MAPTALOX5 | |
| SCHEMBL3554869 | 0.71 | RAB9A (0.52) | NPC1RAB9AMAPTTP53SMN1; SMN2 | |
| SCHEMBL13140345 | 0.71 | ALOX5 (0.56) | NPC1RAB9AMAPTALOX5PPARA | |
| SCHEMBL9263735 | 0.70 | NPC1 (0.54) | NPC1RAB9AMAPTALOX5PPARA | |
| SCHEMBL6224552 | 0.69 | HSD17B10 (0.50) | MAPTPPARAPPARGLMNA | |
| SCHEMBL9261010 | 0.69 | PPARG (0.51) | NPC1RAB9AMAPTALOX5PPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1663936-B1 | BIARYLOXYMETHYLARENE-CARBOXYLIC ACIDS | HOFFMANN LA ROCHE (CH) | 2008-01-09 | — | — | EP | claimed |