Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 6/20 | 0.50 |
| ▸ | RAB9A | P51151 | 6/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | HTT | P42858 | 5/20 | 0.46 |
| ▸ | LMNA | P02545 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | CASP3 | P42574 | 1/20 | 0.44 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.44 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.44 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4675161 | 0.90 | NPC1 (0.54) | NPC1RAB9ASMN1; SMN2MAPTLMNA | |
| SCHEMBL3554869 | 0.81 | RAB9A (0.52) | NPC1RAB9ASMN1; SMN2MAPTHTT | |
| SCHEMBL4672078 | 0.76 | PPARD (0.50) | NPC1RAB9AMAPTKDM4EFFAR1 | |
| SCHEMBL9428441 | 0.76 | KDM4E (0.58) | NPC1RAB9ASMN1; SMN2MAPTHTT | |
| SCHEMBL4677512 | 0.76 | KCNH2 (0.53) | NPC1RAB9AMAPTLMNAKDM4E | |
| SCHEMBL1756437 | 0.74 | PPARD (0.53) | NPC1RAB9ASMN1; SMN2MAPTLMNA | |
| SCHEMBL6527094 | 0.74 | RAB9A (0.62) | NPC1RAB9ASMN1; SMN2MAPTKDM4E | |
| SCHEMBL9428612 | 0.72 | PTGS2 (0.51) | NPC1RAB9ASMN1; SMN2MAPTKDM4E | |
| SCHEMBL9428747 | 0.72 | ALOX5 (0.60) | NPC1RAB9ASMN1; SMN2MAPTKDM4E | |
| SCHEMBL19509921 | 0.72 | ALDH1A1 (0.60) | NPC1RAB9ASMN1; SMN2MAPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1663936-B1 | BIARYLOXYMETHYLARENE-CARBOXYLIC ACIDS | HOFFMANN LA ROCHE (CH) | 2008-01-09 | — | — | EP | claimed |