Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 6/20 | 0.39 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.38 |
| ▸ | TAOK3 | Q9H2K8 | 3/20 | 0.37 |
| ▸ | TAOK1 | Q7L7X3 | 2/20 | 0.37 |
| ▸ | APOB | P04114 | 2/20 | 0.37 |
| ▸ | MTTP | P55157 | 2/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL467518 | 1.00 | FAAH (0.39) | FAAHMCHR1TAOK3TAOK1APOB | |
| SCHEMBL2056589 | 0.84 | DRD2 (0.42) | MCHR1APOBMTTPRAB9ADRD2 | |
| SCHEMBL2056591 | 0.84 | DRD2 (0.42) | MCHR1APOBMTTPRAB9ADRD2 | |
| SCHEMBL13211824 | 0.81 | MCHR1 (0.37) | MCHR1APOBMTTPRAB9ANPC1 | |
| SCHEMBL2056692 | 0.77 | ADRA2A (0.38) | MCHR1RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL467520 | 0.77 | ADRA2A (0.38) | MCHR1RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL12732357 | 0.73 | FAAH (0.57) | FAAH | |
| SCHEMBL467615 | 0.73 | HRH3 (0.42) | FAAHRAB9ANPC1SMN1; SMN2 | |
| SCHEMBL1638017 | 0.73 | HRH3 (0.42) | FAAHRAB9ANPC1SMN1; SMN2 | |
| SCHEMBL467616 | 0.73 | HRH3 (0.42) | FAAHRAB9ANPC1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2387395-A1 | AXL INHIBITORS FOR USE IN COMBINATION THERAPY FOR PREVENTING, TREATING OR MANAGING METASTATIC CANCER | Rigel Pharmaceuticals, Inc. (US) | 2011-11-23 | — | — | EP | disclosed |
| US-8040491-B2 | Exposure method, substrate stage, exposure apparatus, and device manufacturing method | NIKON CORPORATION (JP) | 2011-10-18 | — | — | US | disclosed |
| WO-2010083465-A1 | AXL INHIBITORS FOR USE IN COMBINATION THERAPY FOR PREVENTING, TREATING OR MANAGING METASTATIC CANCER | RIGEL PHARMACEUTICALS, INC. (US) | 2010-07-22 | — | — | WO | disclosed |