Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 4/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | DRD1 | P21728 | 1/20 | 0.36 |
| ▸ | ACLY | P53396 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4733029 | 0.82 | HTR6 (0.46) | HTR6SLC6A4ACLYLMNATHRB | |
| SCHEMBL4670740 | 0.77 | HTR6 (0.67) | HTR6L3MBTL1SLC6A4 | |
| SCHEMBL4670855 | 0.68 | HTR6 (0.51) | HTR6L3MBTL1NPSR1SLC6A4 | |
| SCHEMBL4677214 | 0.68 | HTR6 (0.42) | HTR6L3MBTL1SLC6A4CHRM1DRD2 | |
| SCHEMBL4671281 | 0.67 | HTR6 (0.76) | HTR6SLC6A4LMNATHRB | |
| SCHEMBL4674305 | 0.67 | HTR6 (0.82) | HTR6SLC6A4 | |
| SCHEMBL7499298 | 0.67 | HTR6 (0.47) | HTR6 | |
| SCHEMBL7485051 | 0.65 | HTR6 (0.79) | HTR6SLC6A4 | |
| SCHEMBL4673642 | 0.64 | HTR6 (0.73) | HTR6 | |
| SCHEMBL4671006 | 0.64 | HTR6 (0.73) | HTR6SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1173432-B9 | PIPERIDINE-INDOLE COMPOUNDS HAVING 5-HT6 AFFINITY | NPS ALLELIX CORP (CA) | 2008-10-15 | — | — | EP | disclosed |
| EP-1173432-B1 | PIPERIDINE-INDOLE COMPOUNDS HAVING 5-HT6 AFFINITY | NPS ALLELIX CORP (CA) | 2007-10-17 | — | — | EP | disclosed |