Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 7/20 | 0.46 |
| ▸ | ACLY | P53396 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4675218 | 0.82 | HTR6 (0.45) | HTR6ACLYTHRBLMNASLC6A4 | |
| SCHEMBL4671006 | 0.78 | HTR6 (0.73) | HTR6CYP3A4CYP2D6SLC6A4 | |
| SCHEMBL4677214 | 0.76 | HTR6 (0.42) | HTR6THRBLMNAKDM4EMEN1 | |
| SCHEMBL7499298 | 0.72 | HTR6 (0.47) | HTR6 | |
| SCHEMBL24107949 | 0.71 | LMNA (0.52) | HTR6ACLYTHRBLMNA | |
| SCHEMBL4671073 | 0.71 | HTR6 (0.74) | HTR6CYP3A4CYP2D6SLC6A4 | |
| SCHEMBL4674305 | 0.70 | HTR6 (0.82) | HTR6CYP3A4CYP2D6SLC6A4 | |
| SCHEMBL4671035 | 0.70 | HTR6 (0.59) | HTR6CYP3A4CYP2D6SLC6A4 | |
| SCHEMBL4671281 | 0.69 | HTR6 (0.76) | HTR6CYP3A4CYP2D6THRBLMNA | |
| SCHEMBL14953618 | 0.68 | ACLY (0.61) | ACLYLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1173432-B9 | PIPERIDINE-INDOLE COMPOUNDS HAVING 5-HT6 AFFINITY | NPS ALLELIX CORP (CA) | 2008-10-15 | — | — | EP | claimed |
| EP-1173432-B1 | PIPERIDINE-INDOLE COMPOUNDS HAVING 5-HT6 AFFINITY | NPS ALLELIX CORP (CA) | 2007-10-17 | — | — | EP | claimed |