Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 8/20 | 0.54 |
| ▸ | DRD2 | P14416 | 3/20 | 0.50 |
| ▸ | DRD3 | P35462 | 3/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | DRD4 | P21917 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | BCL2A1 | Q16548 | 1/20 | 0.41 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.40 |
| ▸ | SGK1 | O00141 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4675814 | 0.88 | HTR6 (0.70) | HTR6DRD2DRD3HTR1ADRD4 | |
| SCHEMBL4675303 | 0.86 | HTR6 (0.50) | HTR6DRD2DRD3LMNAHRH4 | |
| SCHEMBL4675659 | 0.83 | HTR6 (0.55) | HTR6DRD2LMNAKMT2AHRH4 | |
| SCHEMBL5201209 | 0.83 | HTR6 (0.78) | HTR6DRD2DRD3LMNAKMT2A | |
| SCHEMBL4675283 | 0.81 | HTR6 (0.76) | HTR6DRD2DRD3LMNAKMT2A | |
| SCHEMBL4675570 | 0.73 | HTR6 (0.71) | HTR6LMNAALDH1A1HTR1AHTR2A | |
| SCHEMBL4676720 | 0.71 | HTR6 (0.71) | HTR6LMNAALDH1A1HTR1AHTR2A | |
| SCHEMBL7951102 | 0.70 | HTR1A (0.49) | HTR6DRD2DRD3HRH4ALDH1A1 | |
| SCHEMBL5204854 | 0.70 | HTR6 (1.00) | HTR6DRD2DRD3HTR1ADRD4 | |
| SCHEMBL3399254 | 0.69 | DRD2 (1.00) | DRD2DRD3HTR1ADRD4HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1542973-B1 | 2,4-SUBSTITUTED INDOLES AND THEIR USE AS 5-HT6 MODULATORS | HOFFMANN LA ROCHE (CH) | 2008-07-30 | — | — | EP | claimed |
| EP-1542973-A1 | 2,4-SUBSTITUTED INDOLES AND THEIR USE AS 5-HT6 MODULATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2005-06-22 | — | — | EP | claimed |
| WO-2004026831-A1 | 2,4-SUBSTITUTED INDOLES AND THEIR USE AS 5-HT6 MODULATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2004-04-01 | — | — | WO | claimed |
| EP-1542973-B1 | 2,4-SUBSTITUTED INDOLES AND THEIR USE AS 5-HT6 MODULATORS | HOFFMANN LA ROCHE (CH) | 2008-07-30 | — | — | EP | disclosed |
| EP-1542973-B1 | 2,4-SUBSTITUTED INDOLES AND THEIR USE AS 5-HT6 MODULATORS | HOFFMANN LA ROCHE (CH) | 2008-07-30 | — | — | EP | disclosed |
| US-7381739-B2 | Antiserotonine agents; central nervous system disorders; Alzheimer's disease; Parkinson's disease; Huntington's disease; sleep disorders | ROCHE PALO ALTO LLC (US) | 2008-06-03 | — | — | US | disclosed |
| US-7381739-B2 | Antiserotonine agents; central nervous system disorders; Alzheimer's disease; Parkinson's disease; Huntington's disease; sleep disorders | ROCHE PALO ALTO LLC (US) | 2008-06-03 | — | — | US | disclosed |
| EP-1542973-A1 | 2,4-SUBSTITUTED INDOLES AND THEIR USE AS 5-HT6 MODULATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2005-06-22 | — | — | EP | disclosed |
| WO-2004026831-A1 | 2,4-SUBSTITUTED INDOLES AND THEIR USE AS 5-HT6 MODULATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2004-04-01 | — | — | WO | disclosed |