Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 2/20 | 0.54 |
| ▸ | MMP12 | P39900 | 1/20 | 0.46 |
| ▸ | MMP13 | P45452 | 1/20 | 0.46 |
| ▸ | FPR2 | P25090 | 5/20 | 0.44 |
| ▸ | PROKR1 | Q8TCW9 | 5/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.41 |
| ▸ | HRH1 | P35367 | 2/20 | 0.41 |
| ▸ | CCR3 | P51677 | 2/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ACACB | O00763 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4675437 | 1.00 | MMP1 (0.54) | MMP1MMP12MMP13FPR2PROKR1 | |
| SCHEMBL4673329 | 0.86 | MMP1 (0.59) | MMP1MMP12MMP13FPR2PROKR1 | |
| SCHEMBL4673322 | 0.86 | MMP1 (0.59) | MMP1MMP12MMP13FPR2PROKR1 | |
| SCHEMBL4671008 | 0.84 | MMP1 (0.74) | MMP1MMP12MMP13FPR2PROKR1 | |
| SCHEMBL4671004 | 0.84 | MMP1 (0.74) | MMP1MMP12MMP13FPR2PROKR1 | |
| SCHEMBL8096415 | 0.81 | MMP12 (0.45) | MMP1MMP12MMP13FPR2PROKR1 | |
| SCHEMBL4671098 | 0.79 | SMN1; SMN2 (0.46) | MMP13MAPTSMN1; SMN2 | |
| SCHEMBL4671091 | 0.79 | SMN1; SMN2 (0.46) | MMP13MAPTSMN1; SMN2 | |
| SCHEMBL4673324 | 0.78 | MMP1 (0.59) | MMP1MMP12MMP13FPR2PROKR1 | |
| SCHEMBL4673327 | 0.78 | MMP1 (0.59) | MMP1MMP12MMP13FPR2PROKR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0958287-B2 | SULFAMIDE-METALLOPROTEASE INHIBITORS | HOFFMANN LA ROCHE (CH) | 2008-04-09 | — | — | EP | disclosed |
| EP-0958287-B1 | SULFAMIDE-METALLOPROTEASE INHIBITORS | HOFFMANN LA ROCHE (CH) | 2002-09-11 | — | — | EP | disclosed |